{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:43:08Z","timestamp":1771864988000,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,5,1]]},"abstract":"<jats:p>1. Plasma noradrenaline concentrations and dopamine \u03b2-hydroxylase activity have been measured at various stages in the development of hypertension in the one-kidney Goldblatt rat (unilateral renal arterial constriction and contralateral nephrectomy).<\/jats:p>\n               <jats:p>2. Although plasma noradrenaline concentrations were significantly elevated from control values at 7, 14 and 28 days, plasma dopamine \u03b2-hydroxylase activity was not significantly different from control values except at 24 h.<\/jats:p>\n               <jats:p>3. These findings suggest that peripheral sympathetic activity is increased in the one-kidney Goldblatt model of experimental hypertension but that plasma dopamine \u03b2-hydroxylase activity is a poor index of this increase.<\/jats:p>\n               <jats:p>4. Both the rise in blood pressure and the rise in plasma noradrenaline concentrations were prevented by pretreatment with intracisternal 6-hydroxydopamine, suggesting that the increased sympathetic activity is at least in part centrally mediated.<\/jats:p>","DOI":"10.1042\/cs0520477","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:32:03Z","timestamp":1438929123000},"page":"477-483","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma Noradrenaline Concentrations in Experimental Renovascular Hypertension in the Rat"],"prefix":"10.1042","volume":"52","author":[{"given":"H. J.","family":"Dargie","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/5\/477\/739439\/cs0520477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/5\/477\/739439\/cs0520477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T17:56:27Z","timestamp":1572198987000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/52\/5\/477\/70815\/Plasma-Noradrenaline-Concentrations-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1977,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0520477","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,5,1]]}}}