{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T19:58:41Z","timestamp":1648756721742},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,7,1]]},"abstract":"<jats:p>1. The isolated choroid plexus of the rabbit takes up 5-methyltetrahydrofolate from the incubation medium.<\/jats:p>\n               <jats:p>2. Other folate analogues (pteroylglutamic acid, methotrexate, 5-formyltetrahydrofolate = folinic acid) inhibited the uptake of 5-methyltetrahydrofolate.<\/jats:p>\n               <jats:p>3. The uptake of 5-methyltetrahydrofolate was inhibited by low temperature, anaerobic conditions and dinitrophenol.<\/jats:p>\n               <jats:p>4. The anticonvulsant drugs, diphenylhydantoin and phenobarbital, had no effect on 5-methyltetrahydrofolate uptake.<\/jats:p>\n               <jats:p>5. The inhibitory effect of pteroylglutamic acid on the uptake of 5-methyltetrahydrofolate by the choroid plexus may explain the effect of long-term folic acid therapy in aggravating vitamin B12 neuropathy in pernicious anaemia.<\/jats:p>","DOI":"10.1042\/cs0530075","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:33:02Z","timestamp":1438929182000},"page":"75-80","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Anticonvulsants on the Uptake of 5-Methyltetrahydrofolic Acid by the Choroid Plexus in Rabbits"],"prefix":"10.1042","volume":"53","author":[{"given":"H.","family":"Taguchi","sequence":"first","affiliation":[{"name":"Haematology Section, Clinical Research Centre, Harrow, Middlesex, and University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Abdul-Cader","sequence":"additional","affiliation":[{"name":"Haematology Section, Clinical Research Centre, Harrow, Middlesex, and University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Perry","sequence":"additional","affiliation":[{"name":"Haematology Section, Clinical Research Centre, Harrow, Middlesex, and University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. H.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Haematology Section, Clinical Research Centre, Harrow, Middlesex, and University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Chanarin","sequence":"additional","affiliation":[{"name":"Haematology Section, Clinical Research Centre, Harrow, Middlesex, and University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/53\/1\/75\/740862\/cs0530075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/53\/1\/75\/740862\/cs0530075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T19:44:31Z","timestamp":1572119071000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/53\/1\/75\/70853\/Effect-of-Anticonvulsants-on-the-Uptake-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0530075","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,7,1]]}}}