{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T02:57:57Z","timestamp":1648522677984},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,7,1]]},"abstract":"<jats:p>1. Oxygen breath tests were performed in seven patients with thyrotoxicosis. The inspired air was replaced by oxygen without their knowledge for 20 s and the fall in ventilation was recorded.<\/jats:p>\n               <jats:p>2. Ventilation fell significantly in all the patients within 40 s. The mean fall was 21\u00b71% (se \u00b1 1\u00b77) below the control value.<\/jats:p>\n               <jats:p>3. \u03b2-Adrenoreceptor blockade with propranolol had little effect on this reduction in ventilation. The fall observed in five patients receiving propranolol was 19\u00b76% (se \u00b1 1\u00b70).<\/jats:p>\n               <jats:p>4. After definitive treatment, which rendered the patients euthyroid, the observed reduction in ventilation after breathing oxygen was significantly less at 11\u00b77% (se \u00b1 1\u00b72).<\/jats:p>\n               <jats:p>5. It is concluded that patients with thyrotoxicosis have an increased resting reflex hypoxic drive to respiration, when compared with the euthyroid state, and this is unaffected by \u03b2-adrenoreceptor blockade.<\/jats:p>","DOI":"10.1042\/cs0530093","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:33:02Z","timestamp":1438943582000},"page":"93-100","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Thyrotoxicosis on the Reflex Hypoxic Respiratory Drive"],"prefix":"10.1042","volume":"53","author":[{"given":"R. A.","family":"Stockley","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/53\/1\/93\/740902\/cs0530093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/53\/1\/93\/740902\/cs0530093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T10:10:45Z","timestamp":1572084645000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/53\/1\/93\/70858\/Effect-of-Thyrotoxicosis-on-the-Reflex-Hypoxic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0530093","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,7,1]]}}}