{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:34:03Z","timestamp":1648773243259},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,8,1]]},"abstract":"<jats:p>1. Neither the mechanism nor the therapeutic implications of the ability of ethacrynic acid to stimulate renal H+ secretion has been fully explored. Acute studies were carried out in six normal volunteer subjects to determine whether or not the stimulation of H+ excretion depended upon sodium chloride or volume depletion.<\/jats:p>\n               <jats:p>2. Depletion was either not corrected, or corrected by one of the following: oral water alone or sodium chloride solution (either 153 mmol\/l or 513 mmol\/l) intravenously to give zero or slightly positive balances of water, sodium chloride or both at all times. Urine was collected at 2 h intervals before and for 8 h after 100 mg of ethacrynic acid. Electrolytes, pH, total acid, osmolality and true creatinine were measured in each urine specimen and in the serum during the control period and 5\u00b75 h after ethacrynic acid.<\/jats:p>\n               <jats:p>3. In all 14 experiments in six subjects, urinary pH was reduced to a mean value 4\u00b778 \u00b1 se 0\u00b708 within 2\u20138 h after ethacrynic acid irrespective of replacement therapy, indicating that the sodium chloride and volume depletions produced by ethacrynic acid were not essential to its effect on urinary pH.<\/jats:p>\n               <jats:p>4. Urinary pH correlated inversely (r = \u22120\u00b781) with the logarithm of the difference between rejected chloride and sodium per unit of rejected chloride, suggesting that the discrepancy between anion-cation reabsorption was intimately linked to generation of H+ gradients, possibly by reducing chloride transport.<\/jats:p>\n               <jats:p>5. Three of the subjects were given amiloride (20 mg) with ethacrynic acid: both the pH reduction and the chloride\/sodium differentials were abolished, probably by reduction of tubular sodium reabsorption. A specific but opposite effect of both agents on tubular H+ transport cannot be excluded.<\/jats:p>","DOI":"10.1042\/cs0530125","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:33:02Z","timestamp":1438943582000},"page":"125-132","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Independence of Ethacrynic Acid-Induced Renal Hydrogen Ion Excretion of Sodium-Volume Depletion in Man"],"prefix":"10.1042","volume":"53","author":[{"given":"A. Z.","family":"Gy\u00f6ry","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Sydney, The Royal North Shore Hospital, St Leonards, N.S.W., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Lissner","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Sydney, The Royal North Shore Hospital, St Leonards, N.S.W., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/53\/2\/125\/753943\/cs0530125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/53\/2\/125\/753943\/cs0530125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T20:30:18Z","timestamp":1572035418000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/53\/2\/125\/70661\/Independence-of-Ethacrynic-AcidInduced-Renal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0530125","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,8,1]]}}}