{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T06:13:49Z","timestamp":1648880029396},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,10,1]]},"abstract":"<jats:p>1. One-year-old male rats were injected intravenously with 200 pmol of 25-hydroxy[26(27)-methyl-3H]cholecalciferol per 100 g body weight and the presence of this metabolite of vitamin D, as well as other metabolites, produced during the following 8 h was examined in serum, urine and bile.<\/jats:p>\n               <jats:p>2. The chromatography data indicated an excretion of 25-hydroxycholecalciferol both in bile and urine and, in urine, also of 1,25-dihydroxycholecalciferol. In bile, fractions of labelled substances were also obtained which, according to their elution positions, might represent cholecalciferol and conjugated metabolites.<\/jats:p>\n               <jats:p>3. The excretion of active metabolites of vitamin D in normal urine might be elevated in chronic renal failure and, in conjunction with a reduced synthesis, contribute to the occurrence of renal osteodystrophy.<\/jats:p>","DOI":"10.1042\/cs0530373","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:33:02Z","timestamp":1438943582000},"page":"373-377","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excretion of Active Metabolites of Vitamin D in Urine and Bile of the Adult Rat"],"prefix":"10.1042","volume":"53","author":[{"given":"S.-E.","family":"Larsson","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Ume\u00e5, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lorentzon","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Ume\u00e5, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/53\/4\/373\/739940\/cs0530373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/53\/4\/373\/739940\/cs0530373.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T02:14:11Z","timestamp":1571969651000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/53\/4\/373\/70908\/Excretion-of-Active-Metabolites-of-Vitamin-D-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1977,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0530373","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,10,1]]}}}