{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T05:36:52Z","timestamp":1697953012846},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,3,1]]},"abstract":"<jats:p>1. Muscle electrolyte (Na, K, Cl, P) concentrations and fluid compartments of six children with Bartter's syndrome were compared with those of 17 control children. From four of the patients biopsies were taken twice, before and after treatment with potassium chloride and spironolactone. Muscle electrolytes were determined by neutron activation in tissue sampled by needle biopsy. Results were expressed in relation to fat-free dry solids. Trapped extracellular fluid was calculated from the chloride space, a normal resting membrane potential being assumed.<\/jats:p>\n               <jats:p>2. In hypokalaemic patients total muscle potassium (Km) (33\u00b70 \u00b1 2\u00b71 sem) was below the normal range (43\u00b78 \u00b1 0\u00b77 mmol\/100 g of fat-free dry solids) in all cases. When plasma potassium was corrected, total muscle potassium returned to normal. There was a significant correlation between plasma potassium concentration and total muscle potassium (r = 0\u00b787; P &lt; 0\u00b701). Total muscle sodium (Nam) was increased: 18\u00b77 \u00b1 2\u00b79 mmol\/100 g in hypokalaemic patients (11\u00b73 \u00b1 0\u00b76 mmol\/100 g of fat-free dry solids in control subjects). A negative relationship was found between Km and Nam (r = \u20140\u00b785; P &lt; 0\u00b701). With treatment, intracellular potassium concentration remained low (142\u00b70 mmol\/l of intracellular water; control, 163\u00b70 \u00b1 2\u00b74 mmol\/l) despite normokalaemia and normal total muscle potassium. Muscle phosphorus (32\u00b71 \u00b1 1\u00b78 mmol\/100 g) was higher than in control subjects (28\u00b71 \u00b1 0\u00b74 mmol\/100 g of fat-free dry solids).<\/jats:p>\n               <jats:p>3. These data suggest that sodium replaces potassium in muscle of patients with Bartter's syndrome. The low intracellular potassium concentration in the binephrectomized sister of one child and in all treated children suggests that there are generalized anomalies in the handling of cations in Bartter's syndrome.<\/jats:p>","DOI":"10.1042\/cs0540223","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:34:03Z","timestamp":1438929243000},"page":"223-231","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Muscle Electrolytes and Fluid Compartments in Six Children with Bartter's Syndrome"],"prefix":"10.1042","volume":"54","author":[{"given":"Christine","family":"Delaporte","sequence":"first","affiliation":[{"name":"Clinique des Maladies du Rein et du M\u00e9labolisme chez l'Enfant and the Clinique de P\u00e9diatrie de l'U.E.R. Xavier-Bichat, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Stulzaft","sequence":"additional","affiliation":[{"name":"Clinique des Maladies du Rein et du M\u00e9labolisme chez l'Enfant and the Clinique de P\u00e9diatrie de l'U.E.R. Xavier-Bichat, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Loirat","sequence":"additional","affiliation":[{"name":"Clinique des Maladies du Rein et du M\u00e9labolisme chez l'Enfant and the Clinique de P\u00e9diatrie de l'U.E.R. Xavier-Bichat, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Broyer","sequence":"additional","affiliation":[{"name":"Clinique des Maladies du Rein et du M\u00e9labolisme chez l'Enfant and the Clinique de P\u00e9diatrie de l'U.E.R. Xavier-Bichat, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/3\/223\/754087\/cs0540223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/3\/223\/754087\/cs0540223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T20:59:53Z","timestamp":1572123593000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/54\/3\/223\/71180\/Muscle-Electrolytes-and-Fluid-Compartments-in-Six"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0540223","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1978,3,1]]}}}