{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:26:52Z","timestamp":1648700812994},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,4,1]]},"abstract":"<jats:p>1. Mice were infected with fertile bisexual Schistosoma mansoni and compared with similar animals infected with unisexual worms or sterile bisexual worms.<\/jats:p>\n               <jats:p>2. A significant increase in splenic weight occurred in all infected animals.<\/jats:p>\n               <jats:p>3. Administration of well-tolerated doses of 6-mercaptopurine abolished the increase in relative splenic weight in animals infected with ordinary S. mansoni.<\/jats:p>\n               <jats:p>4. In splenectomized uninfected mice leucocytosis but no other haematological changes developed.<\/jats:p>\n               <jats:p>5. In splenectomized mice lower values for packed cell volume were observed 8 weeks after, but not 12 weeks after, infection with S. mansoni.<\/jats:p>\n               <jats:p>6. Slight prolongation of the life-span of erythrocytes occurred in splenectomized infected mice.<\/jats:p>\n               <jats:p>7. It is concluded that anaemia in schistosomiasis depends to a significant extent on immunity developed to adult schistosomal worms and can develop in the absence of schistosomal ova.<\/jats:p>\n               <jats:p>8. The anaemia resulting from such an immune response may be suppressed by administration of 6-mercaptopurine.<\/jats:p>\n               <jats:p>9. Such anaemia occurs even in splenectomized mice; thus hypersplenism is not necessary for its development although splenectomy slightly prolongs the erythrocyte life-span.<\/jats:p>","DOI":"10.1042\/cs0540397","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:34:03Z","timestamp":1438943643000},"page":"397-401","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Causation of Splenomegaly in Schistosomiasis in Mice"],"prefix":"10.1042","volume":"54","author":[{"given":"Adel A. F.","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Department of Clinical Tropical Medicine, London School of Hygiene and Tropical Medicine, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"Woodruff","sequence":"additional","affiliation":[{"name":"Department of Clinical Tropical Medicine, London School of Hygiene and Tropical Medicine, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/4\/397\/740132\/cs0540397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/4\/397\/740132\/cs0540397.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T12:43:40Z","timestamp":1572180220000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/54\/4\/397\/71022\/The-Causation-of-Splenomegaly-in-Schistosomiasis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0540397","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1978,4,1]]}}}