{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T11:29:10Z","timestamp":1649158150699},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,5,1]]},"abstract":"<jats:p>1. Liver biopsies from two patients with the Dubin\u2014Johnson\u2014Sprinz syndrome were subjected to analytical subcellular fractionation by sucrose-density-gradient centrifugation and enzymic micro-assays.<\/jats:p>\n               <jats:p>2. A selective deficiency of mitochondrial superoxide dismutase has been demonstrated in these patients.<\/jats:p>\n               <jats:p>3. The significance of this enzyme deficiency is discussed in relation to the organelle pathology of the syndrome.<\/jats:p>","DOI":"10.1042\/cs0540549","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:34:03Z","timestamp":1438943643000},"page":"549-553","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Organelle Pathology and Demonstration of Mitochondrial Superoxide Dismutase Deficiency in Two Patients with Dubin\u2013Johnson\u2013Sprinz Syndrome"],"prefix":"10.1042","volume":"54","author":[{"given":"T. J.","family":"Peters","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Seymour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/5\/549\/740207\/cs0540549.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/5\/549\/740207\/cs0540549.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T04:01:18Z","timestamp":1572062478000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/54\/5\/549\/71197\/The-Organelle-Pathology-and-Demonstration-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0540549","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1978,5,1]]}}}