{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T06:45:55Z","timestamp":1648622755114},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,6,1]]},"abstract":"<jats:p>1. A relationship between bacterial endotoxin absorbed from the gut and acute renal failure has been postulated. Experiments employing either the endotoxin-tolerant state or the enhancement of endotoxin injury were undertaken to test this relationship in rats.<\/jats:p>\n               <jats:p>2. Endotoxin tolerance was induced by the administration of increasing doses of Escherichia coli 026 lipopolysaccharide. The severity of renal injury was assessed at various times after glycerol administration in endotoxin-tolerant and control animals. At 48 h, endotoxin-tolerant rats had higher urine volume and creatinine clearance than the non-tolerant control animals. In rats studied 72 h after glycerol, functional and anatomical assessment showed the endotoxin-tolerant rats to have lower serum urea concentrations and also less renal histological injury than the non-tolerant, control animals.<\/jats:p>\n               <jats:p>3. Lead acetate, which potentiates endotoxin injury, or diluent alone was administered to rats after glycerol. At 2, 3 and 10 days later there was a twofold increase in mortality in the lead acetate-treated animals.<\/jats:p>\n               <jats:p>4. A small dose of endotoxin (0\u00b71 mg) was shown to be innocuous in control rats. Also, all rats given glycerol alone were alive 24 h later. In contrast, administration of the same dose of endotoxin simultaneously with glycerol resulted in an 80% mortality at 24 h.<\/jats:p>\n               <jats:p>5. These studies demonstrate enhancement of glycerol-induced renal injury by endotoxin and support a possible role for endotoxin in this model of acute renal failure.<\/jats:p>","DOI":"10.1042\/cs0540615","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:34:03Z","timestamp":1438943643000},"page":"615-620","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Endotoxin in Glycerol-Induced Renal Failure in the Rat"],"prefix":"10.1042","volume":"54","author":[{"given":"J. P.","family":"Nolan","sequence":"first","affiliation":[{"name":"Department of Medicine, The State University of New York at Buffalo and the Buffalo General Hospital, Buffalo, New York, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Venuto","sequence":"additional","affiliation":[{"name":"Department of Medicine, The State University of New York at Buffalo and the Buffalo General Hospital, Buffalo, New York, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwendolyn S.","family":"Goldmann","sequence":"additional","affiliation":[{"name":"Department of Medicine, The State University of New York at Buffalo and the Buffalo General Hospital, Buffalo, New York, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/6\/615\/818336\/cs0540615.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/6\/615\/818336\/cs0540615.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T13:29:57Z","timestamp":1572010197000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/54\/6\/615\/70883\/Role-of-Endotoxin-in-GlycerolInduced-Renal-Failure"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0540615","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1978,6,1]]}}}