{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:31:40Z","timestamp":1715538700397},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,7,1]]},"abstract":"<jats:p>1. The 24 h urinary excretion of kallikrein has been studied in 40 normotensive control subjects and in 74 age-matched patients with essential hypertension under similar conditions. By use of the renin-sodium index, hypertensive patients were divided into two subgroups: low-renin hypertension and normal-renin hypertension patients. Urinary kallikrein determinations were also obtained from six hypertensive patients with primary aldosteronism.<\/jats:p>\n               <jats:p>2. Urinary kallikrein was significantly lower both in patients with normal-renin and low-renin essential hypertension. Urinary kallikrein excretion was very high in the patients with primary aldosteronism.<\/jats:p>\n               <jats:p>3. In nine hypertensive patients \u03b2-adrenoreceptor-blocking therapy caused a significant decrease of plasma renin activity, but had no significant effect on urinary kallikrein excretion.<\/jats:p>\n               <jats:p>4. The results support the concept that low urinary kallikrein is likely to be a marker of essential hypertension. Under certain conditions its excretion is positively related to mineralocorticoid hormone concentrations but it is not primarily related to the renin-angiotensin system.<\/jats:p>","DOI":"10.1042\/cs0550051","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:34:59Z","timestamp":1438943699000},"page":"51-55","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Urinary Kallikrein Excretion and Plasma Renin Activity in Patients with Essential Hypertension and Primary Aldosteronism"],"prefix":"10.1042","volume":"55","author":[{"given":"A.","family":"Lechi","sequence":"first","affiliation":[{"name":"Istituto di Clinica Medica e Cattedra di Clinica e Microscopia Clinica dell'Universit\u00e0 di Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Covi","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Medica e Cattedra di Clinica e Microscopia Clinica dell'Universit\u00e0 di Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lechi","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Medica e Cattedra di Clinica e Microscopia Clinica dell'Universit\u00e0 di Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Corgnati","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Medica e Cattedra di Clinica e Microscopia Clinica dell'Universit\u00e0 di Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Arosio","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Medica e Cattedra di Clinica e Microscopia Clinica dell'Universit\u00e0 di Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zatti","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Medica e Cattedra di Clinica e Microscopia Clinica dell'Universit\u00e0 di Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A.","family":"Scuro","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Medica e Cattedra di Clinica e Microscopia Clinica dell'Universit\u00e0 di Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/1\/51\/837333\/cs0550051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/1\/51\/837333\/cs0550051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T21:53:37Z","timestamp":1572213217000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/55\/1\/51\/71226\/Urinary-Kallikrein-Excretion-and-Plasma-Renin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0550051","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1978,7,1]]}}}