{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T23:58:22Z","timestamp":1648771102482},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,9,1]]},"abstract":"<jats:p>1. Jejunal biopsies from five patients with non-responsive coeliac disease have been subjected to analytical subcellular fractionation and enzymic microassay in order to compare the organelle pathology of this group with untreated but gluten-sensitive patients.<\/jats:p>\n               <jats:p>2. Compared with the gluten-sensitive group these non-responsive patients showed marked reduction of the endoplasmic reticulum enzymes, normal activities of lysosomal enzymes and slightly less severely reduced brush border activities.<\/jats:p>\n               <jats:p>3. It is suggested that the present biochemical studies in combination with previous clinical reports and measurements of DNA and protein synthesis by cultured mucosal biopsies delineate non-responsive coeliac disease as a distinct entity.<\/jats:p>\n               <jats:p>4. The patients were treated with oral prednisolone (20 mg daily) for between 5 and 9 weeks and the properties of the jejunal biopsies restudied.<\/jats:p>\n               <jats:p>5. Although morphologically there was only a partial restoration of the villus architecture the enzymic alterations and organelle abnormalities returned essentially to normal values.<\/jats:p>","DOI":"10.1042\/cs0550293","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:34:59Z","timestamp":1438943699000},"page":"293-300","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analytical Subcellular Fractionation of Jejunal Biopsy Specimens: Enzyme Activities, Organelle Pathology and Response to Corticosteroids in Patients with Non-Responsive Coeliac Disease"],"prefix":"10.1042","volume":"55","author":[{"given":"T.J.","family":"Peters","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.J.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gill","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/3\/293\/451448\/cs0550293.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/3\/293\/451448\/cs0550293.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T20:29:57Z","timestamp":1572121797000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/55\/3\/293\/74120\/Analytical-Subcellular-Fractionation-of-Jejunal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0550293","relation":{},"ISSN":["0143-5221"],"issn-type":[{"value":"0143-5221","type":"print"}],"subject":[],"published":{"date-parts":[[1978,9,1]]}}}