{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:59:41Z","timestamp":1715540381725},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,11,1]]},"abstract":"<jats:p>1. The haemodynamic effects of oral converting enzyme inhibitor (SQ 14225) were assessed in eight patients with severe essential or renovascular hypertension.<\/jats:p>\n               <jats:p>2. Mean arterial pressure fell (149 \u00b1 5 to 127 \u00b1 8 mmHg, P &lt; 0.02), because of a fall in total peripheral resistance (6.9 \u00b1 0.53 to 5.7 \u00b1 0.40 kPa 1-1 s m2) without a significant change in cardiac index. Two of the eight patients were non-responders without pressure reduction or a haemodynamic change. Sodium restriction (10 mmol\/day) while the same dose of SQ 14225 was continued further lowered arterial pressure (137 \u00b1 8 to 111 \u00b1 12 mmHg, P &lt; 0.05) through further resistance reduction (6.5 \u00b1 0.53 to 5.2 \u00b1 0.40 kPa l\u22121 sm2, P &lt; 0.05).<\/jats:p>\n               <jats:p>3. Haemodynamic responses to head-up tilt (increased heart rate and resistance, decreased cardiac index) were unaffected by SQ 14225 regardless of sodium intake.<\/jats:p>\n               <jats:p>4. The pattern of reduction in peripheral resistance, with unchanged cardiac index, was similar to that produced by vasodilators acting at both arteriolar and venular levels.<\/jats:p>","DOI":"10.1042\/cs0550453","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:34:59Z","timestamp":1438929299000},"page":"453-459","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Haemodynamics of Orally-Active Converting Enzyme Inhibitor (SQ 14225) in Hypertensive Patients"],"prefix":"10.1042","volume":"55","author":[{"suffix":"Jr","given":"R. J.","family":"Cody","sequence":"first","affiliation":[{"name":"Research Division, The Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Tarazi","sequence":"additional","affiliation":[{"name":"Research Division, The Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. L.","family":"Bravo","sequence":"additional","affiliation":[{"name":"Research Division, The Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. M.","family":"Fouad","sequence":"additional","affiliation":[{"name":"Research Division, The Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/5\/453\/451402\/cs0550453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/5\/453\/451402\/cs0550453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T22:20:17Z","timestamp":1572042017000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/55\/5\/453\/72317\/Haemodynamics-of-OrallyActive-Converting-Enzyme"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0550453","relation":{},"ISSN":["0143-5221"],"issn-type":[{"value":"0143-5221","type":"print"}],"subject":[],"published":{"date-parts":[[1978,11,1]]}}}