{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:33:17Z","timestamp":1715538797813},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,1,1]]},"abstract":"<jats:p>1. Noradrenaline and adrenaline in the adrenal vein of essential hypertensive patients are almost exclusively (99%) unconjugated or free. However only 17% of dopamine is free, the rest is conjugated. The further the site of sampling from the adrenal vein the closer come the free catecholamines to their normal peripheral venous proportion (noradrenaline + adrenaline 20%, dopamine less than 1% of total catecholamines). Deviations from these patterns help to detect the site and type of secretion of phaeochromocytoma.<\/jats:p>\n               <jats:p>2. Essential hypertensive patients have, compared with control subjects, higher conjugated plasma dopamine, less urinary free and conjugated dopamine with blunted urinary free dopamine and sodium responsiveness to frusemide. Conjugated noradrenaline + adrenaline, mean arterial pressure and age are positively interrelated.<\/jats:p>\n               <jats:p>3. Patients with primary aldosteronism have elevated plasma and urinary total dopamine. After removal of the adenoma urinary dopamine excretion decreases to normal.<\/jats:p>\n               <jats:p>4. Elevated conjugated dopamine appears to reflect a compensatory activation of the dopaminergic vasodilator pathway in hypertension, the total urinary dopamine excretion an intrinsic deficiency or compensatory increase of a dopamine-modulated natriuretic mechanism.<\/jats:p>","DOI":"10.1042\/cs055077s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:34:59Z","timestamp":1438929299000},"page":"77s-80s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Free and Conjugated Catecholamines in Human Hypertension"],"prefix":"10.1042","volume":"55","author":[{"given":"O.","family":"Kuchel","sequence":"first","affiliation":[{"name":"Clinical Research Institute, H\u00f4tel-Dieu Hospital, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. T.","family":"Buu","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, H\u00f4tel-Dieu Hospital, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TH.","family":"Unger","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, H\u00f4tel-Dieu Hospital, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Genest","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, H\u00f4tel-Dieu Hospital, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/s4\/77s\/740538\/cs055077s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/s4\/77s\/740538\/cs055077s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T19:45:02Z","timestamp":1572032702000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/55\/s4\/77s\/101440\/Free-and-Conjugated-Catecholamines-in-Human"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1,1]]},"references-count":0,"journal-issue":{"issue":"s4","published-print":{"date-parts":[[1978,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs055077s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1978,1,1]]}}}