{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:49:14Z","timestamp":1757702954751},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,1,1]]},"abstract":"<jats:p>1. In 27 severe primary hypertensive patients nifedipine (10 mg), administered orally, induced prompt (\u201321% of control at 30 min) and persistent (\u201317% at 120 min) fall of mean arterial pressure mediated through reduction of peripheral vascular resistance with rise of cardiac output.<\/jats:p>\n               <jats:p>2. The sublingual route (nine cases) showed more rapid onset of action and equal antihypertensive effectiveness.<\/jats:p>\n               <jats:p>3. In five patients with hypertensive crisis and acute left ventricular failure, the drug strikingly reduced systemic and pulmonary arterial pressures and relieved pulmonary oedema.<\/jats:p>\n               <jats:p>4. Prompt efficacy, ease of administration, absence of important side effects indicate that nifedipine may be a useful therapeutic agent in severe hypertension and in critical conditions that require rapid lowering of blood pressure.<\/jats:p>","DOI":"10.1042\/cs055291s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:34:59Z","timestamp":1438943699000},"page":"291s-292s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Haemodynamic Effects of a Calcium Antagonistic Agent (Nifedipine) in Hypertension: Therapeutic Implications"],"prefix":"10.1042","volume":"55","author":[{"given":"C.","family":"Bartorelli","sequence":"first","affiliation":[{"name":"Centro ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Istituto di Clinica Medica II and Istituto Ricerche Cardiovascolari, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Magrini","sequence":"additional","affiliation":[{"name":"Centro ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Istituto di Clinica Medica II and Istituto Ricerche Cardiovascolari, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Moruzzi","sequence":"additional","affiliation":[{"name":"Centro ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Istituto di Clinica Medica II and Istituto Ricerche Cardiovascolari, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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