{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T01:32:07Z","timestamp":1648603927597},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,1,1]]},"abstract":"<jats:p>1. Haemodynamic responses to diazoxide (300 mg intravenously) were studied in 15 hypertensive patients before and after chronic \u03b2-adrenoreceptor blockade by 320 mg of propranolol daily. After diazoxide alone, mean arterial pressure and total peripheral resistance were lowered by 24 \u00b1 3 and 35 \u00b1 5% (mean \u00b1 sem) respectively. Cardiac output and heart rate rose by 25 \u00b1 9 and 21 \u00b1 3%. During \u03b2-adrenoreceptor blockade, the percentage changes of mean arterial pressure, heart rate, cardiac output and total peripheral resistance after vasodilatation were not significantly different from those after diazoxide alone.<\/jats:p>\n               <jats:p>2. Atropine, 0\u00b704 mg\/kg body weight, was given to 12 hypertensive patients chronically treated with \u03b2-adrenoreceptor blockade, before acute vasodilatation by diazoxide. Diazoxide caused no increase in heart rate after combined \u03b2-adrenoreceptor and parasympathetic blockade. However, cardiac output rose by 14 \u00b1 5%.<\/jats:p>\n               <jats:p>3. We conclude that withdrawal of parasympathetic tone is an important determinant of circulatory homeostasis after acute vasodilatation during \u03b2-adrenoreceptor blockade.<\/jats:p>","DOI":"10.1042\/cs055329s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:34:59Z","timestamp":1438943699000},"page":"329s-332s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sympathetic and Parasympathetic Components of Reflex Cardiostimulation during Vasodilator Treatment of Hypertension"],"prefix":"10.1042","volume":"55","author":[{"given":"A. J. Man","family":"in 't Veld","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Wenting","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Verhoeven","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A. D. H.","family":"Schalekamp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/s4\/329s\/740696\/cs055329s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/55\/s4\/329s\/740696\/cs055329s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T08:08:08Z","timestamp":1572077288000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/55\/s4\/329s\/101484\/Sympathetic-and-Parasympathetic-Components-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1,1]]},"references-count":0,"journal-issue":{"issue":"s4","published-print":{"date-parts":[[1978,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs055329s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1978,1,1]]}}}