{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T19:11:56Z","timestamp":1695669116510},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,2,1]]},"abstract":"<jats:p>1. The Carworth Long-Evans rat has been reported to develop adrenal-regeneration hypertension but not deoxycorticosterone acetate (DOCA) hypertension. Deficiency of a hypothalamic receptor for deoxycorticosterone which mediates saline polydipsia has been postulated to underlie this resistance. Since a mineralocorticoid etiology for adrenal-regeneration hypertension has been postulated and all mineralocorticoids are thought to act on common receptors, these previous reports are difficult to reconcile.<\/jats:p>\n               <jats:p>2. To determine if an absolute or relative resistance to mineralocorticoids is present, Charles River Long-Evans and Sprague-Dawley rats were given 40 mg (107 \u03bcmol) of DOCA pellets\/rat or 250 \u03bcg (0\u00b765 \u03bcmol) of 2\u03b1-methyl-9\u03b1-fluorocortisol\/day subcutaneously.<\/jats:p>\n               <jats:p>3. Saline polydipsia occurred with both steroids with both rat strains, though significantly less with the Long-Evans rats. Both types of rats became hypertensive and developed cardiac and renal enlargement with both steroids. Hypertension developed more rapidly with 2\u03b1-methyl-9\u03b1-fluorocortisol.<\/jats:p>\n               <jats:p>4. Thus mineralocorticoid hypertension can be produced in the Charles River Long-Evans rat, and the development of adrenal-regeneration hypertension in this rat strain is not incompatible with a mineralocorticoid etiology for adrenal-regeneration hypertension.<\/jats:p>","DOI":"10.1042\/cs0560109","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:35:09Z","timestamp":1438943709000},"page":"109-113","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypertension with Mineralocorticoid Administration to the Long-Evans Rat"],"prefix":"10.1042","volume":"56","author":[{"given":"O. B.","family":"Holland","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center, Dallas, Texas, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gomez-Sanchez","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center, Dallas, Texas, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center, Dallas, Texas, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/56\/2\/109\/451631\/cs0560109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/56\/2\/109\/451631\/cs0560109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:03:05Z","timestamp":1638475385000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/56\/2\/109\/72327\/Hypertension-with-Mineralocorticoid-Administration"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0560109","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,2,1]]}}}