{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:35:36Z","timestamp":1767706536535},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,4,1]]},"abstract":"<jats:p>1. Bone loss was assessed by measurement of cortical thickness of metacarpal bone by X-ray and of trabecular bone area in serial bone biopsies in 49 patients with chronic renal failure, six before and 45 during maintenance haemodialysis treatment.<\/jats:p>\n               <jats:p>2. Metacarpal cortical measurements (MCM) were very reproducible (coefficient of variation 1\u00b795%), whereas bone area measurements by histology showed great variability. There was no correlation between rates of change of MCM and bone area over the same period, although both tended to fall with time.<\/jats:p>\n               <jats:p>3. The mean annual rate of bone loss measured by MCM for patients on dialysis was 2\u00b708 \u00b1 0\u00b732 mm\/year (mean \u00b11 sem) and this rate was not significantly different from the mean rate of loss of 2\u00b749 \u00b1 0\u00b778 mm\/year for the six patients who were not on maintenance haemodialysis. 61% of all patients showed a significant decrease during the period of study (1\u20136 years), but none had symptoms attributable to bone loss.<\/jats:p>\n               <jats:p>4. The loss tended to be greatest in women over the age of 40 years. The initial amount of bone and the rate of loss measured by MCM or bone histology were not influenced significantly by the presence or absence of histological or radiological evidence of parathyroid overactivity or of osteomalacia, nor by differences in the causes of renal disease.<\/jats:p>\n               <jats:p>5. Loss of metacarpal cortical bone correlated with heparin consumption during haemodialysis in men but not in women. The amount of bone and its rate of loss was not influenced by the presence of an arteriovenous shunt in one arm compared with the other. In neither sex did bone loss correlate with physical activity.<\/jats:p>\n               <jats:p>6. A relative deficiency of calcium due to a low dietary calcium intake and intestinal malabsorption of calcium, together with a dialysate calcium of only 1\u00b75 mmol\/l, may be more important causes of bone loss in patients in this study.<\/jats:p>","DOI":"10.1042\/cs0560317","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:35:09Z","timestamp":1438943709000},"page":"317-324","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Loss of Metacarpal and Iliac Bone in Chronic Renal Failure: Influence of Haemodialysis, Parathyroid Activity, Type of Renal Disease, Physical Activity and Heparin Consumption"],"prefix":"10.1042","volume":"56","author":[{"given":"R. G.","family":"Henderson","sequence":"first","affiliation":[{"name":"Renal Unit, Churchill Hospital Sheffield, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G. G.","family":"Russell","sequence":"additional","affiliation":[{"name":"Nuffield Orthopaedic Centre, Oxford, Sheffield, U.K."},{"name":"Department of Chemical Pathology, Sheffield University Medical School, Sheffield, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Earnshaw","sequence":"additional","affiliation":[{"name":"Nuffield Orthopaedic Centre, Oxford, Sheffield, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G. G.","family":"Ledingham","sequence":"additional","affiliation":[{"name":"Renal Unit, Churchill Hospital Sheffield, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. O.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Renal Unit, Churchill Hospital Sheffield, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. G.","family":"Woods","sequence":"additional","affiliation":[{"name":"Nuffield Orthopaedic Centre, Oxford, Sheffield, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/56\/4\/317\/451497\/cs0560317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/56\/4\/317\/451497\/cs0560317.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:01:34Z","timestamp":1638475294000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/56\/4\/317\/72239\/Loss-of-Metacarpal-and-Iliac-Bone-in-Chronic-Renal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0560317","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,4,1]]}}}