{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:59:29Z","timestamp":1715540369397},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,7,1]]},"abstract":"<jats:p>1. Pentolinium tartrate (a ganglionic blocker) was injected in conscious rats during the early and late phases of two-kidney renal hypertension produced by aortic ligation.<\/jats:p>\n               <jats:p>2. In the early phase (5 days after aortic ligation), ganglionic blockade resulted in a decrease in blood pressure equal to that obtained in normotensive rats. Later, at days 12 and 40, for equally severe hypertension, ganglion blockade resulted in a greater decrease in blood pressure.<\/jats:p>\n               <jats:p>3. A 30 min infusion of [Sar1, Ala8]angiotensin II during the pentolinium-induced nadir in blood pressure resulted in a further decrease in blood pressure at day 5. Later, at days 12 and 40, this effect was smaller.<\/jats:p>\n               <jats:p>4. A 300 min infusion of [Sar1, Ala8]angiotensin II normalized the blood pressure in hypertensive rats at day 40. This delayed response may be secondary to a central effect of the antagonist, reducing neurogenic tone or peripheral antagonism of locally generated angiotensin II in the blood vessel walls.<\/jats:p>\n               <jats:p>5. At day 40, removal of the small left kidney resulted in a greater decrease in blood pressure. This suggests the presence of a renal factor other than renin in the chronic phase of this hypertension.<\/jats:p>","DOI":"10.1042\/cs0570025","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"25-29","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neurogenic Activity\u2013Angiotensin II Interaction during the Development and Maintenance of Renal Hypertension in the Rat"],"prefix":"10.1042","volume":"57","author":[{"given":"G.","family":"Bellini","sequence":"first","affiliation":[{"name":"1Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fiorentini","sequence":"additional","affiliation":[{"name":"2Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"3Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Onesti","sequence":"additional","affiliation":[{"name":"4Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hessan","sequence":"additional","affiliation":[{"name":"5Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Gould","sequence":"additional","affiliation":[{"name":"6Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"7Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. E.","family":"Kim","sequence":"additional","affiliation":[{"name":"8Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Swartz","sequence":"additional","affiliation":[{"name":"9Division of Nephrology and Hypertension, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/1\/25\/451909\/cs0570025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/1\/25\/451909\/cs0570025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:02:00Z","timestamp":1638475320000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/1\/25\/72264\/Neurogenic-Activity-Angiotensin-II-Interaction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0570025","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,7,1]]}}}