{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:29:33Z","timestamp":1759541373795},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,8,1]]},"abstract":"<jats:p>1. Jejunal biopsy specimens from three children with congenital sucrase\u2014isomaltase deficiency were assayed for disaccharidase activity and were subjected to analytical subcellular fractionation with enzymic microanalysis.<\/jats:p>\n               <jats:p>2. By use of the highly sensitive fluorigenic modification of the disaccharidase assay, brush-border sucrase and isomaltase activities were depressed but nevertheless detectable in each child.<\/jats:p>\n               <jats:p>3. Apart from the expected decrease in brush-border \u03b1-glucosidase activity, the other enterocyte marker-enzyme activities were normal.<\/jats:p>\n               <jats:p>4. There were no abnormalities in the enterocytes of any child on analytical subcellular fractionation or on electron microscopy.<\/jats:p>","DOI":"10.1042\/cs0570181","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"181-185","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Subcellular Fractionation Studies of the Intestinal Mucosa in Congenital Sucrase\u2014Isomaltase Deficiency"],"prefix":"10.1042","volume":"57","author":[{"given":"B. T.","family":"Cooper","sequence":"first","affiliation":[{"name":"1Department of Medicine, Royal Postgraduate Medical School and Department of Child Health, Institute of Child Health, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C. A.","family":"Candy","sequence":"additional","affiliation":[{"name":"2Department of Medicine, Royal Postgraduate Medical School and Department of Child Health, Institute of Child Health, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. T.","family":"Harries","sequence":"additional","affiliation":[{"name":"3Department of Medicine, Royal Postgraduate Medical School and Department of Child Health, Institute of Child Health, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Peters","sequence":"additional","affiliation":[{"name":"4Department of Medicine, Royal Postgraduate Medical School and Department of Child Health, Institute of Child Health, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/2\/181\/451919\/cs0570181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/2\/181\/451919\/cs0570181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:03:20Z","timestamp":1638475400000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/2\/181\/72340\/Subcellular-Fractionation-Studies-of-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0570181","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,8,1]]}}}