{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:08:56Z","timestamp":1761581336637},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,8,1]]},"abstract":"<jats:p>1. Chronic hypertension was induced in Wistar rats with intact kidneys by subcutaneous implantation of 50 mg of deoxycorticosterone acetate (DOC A) in wax and addition of sodium chloride (9 g\/l) to the drinking water.<\/jats:p>\n               <jats:p>2. The development of DOCA\/salt hypertension, as monitored by tail-cuff plethysmography, was prevented by: (a) destruction of the peripheral adrenergic nerves with neonatal administration of guanethidine (80 mg\/kg subcutaneously for the first 14 days postnatally); (b) bilateral stellate ganglionectomy; (c) oral administration of the \u03b2-adrenoreceptor antagonists propranolol or atenolol (1 mg day\u22121 kg\u22121) during the period of DOCA\/salt treatment.<\/jats:p>\n               <jats:p>3. The dose of DOCA used was sufficient to inhibit the atrial Uptake2 pathway completely: this process appears to participate in termination of action of neurally released noradrenaline in the heart.<\/jats:p>\n               <jats:p>4. It is suggested that this model of DOCA\/salt hypertension is due to adrenergic enhancement of cardiac output in the presence of an increased sodium load. The enhancement may be partly due to deficient myocardial inactivation of noradrenaline.<\/jats:p>","DOI":"10.1042\/cs0570203","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"203-210","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dependence of Deoxycorticosterone\/Salt Hypertension in the Rat on the Activity of Adrenergic Cardiac Nerves"],"prefix":"10.1042","volume":"57","author":[{"given":"C.","family":"Bell","sequence":"first","affiliation":[{"name":"1Department of Physiology, University of Melbourne, and Department of Physiology, Monash University, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elspeth M.","family":"McLachlan","sequence":"additional","affiliation":[{"name":"2Department of Physiology, University of Melbourne, and Department of Physiology, Monash University, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/2\/203\/451954\/cs0570203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/2\/203\/451954\/cs0570203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:03:17Z","timestamp":1638475397000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/2\/203\/72338\/Dependence-of-Deoxycorticosterone-Salt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0570203","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,8,1]]}}}