{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:08:16Z","timestamp":1770487696123,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,9,1]]},"abstract":"<jats:p>1. Sensitivity of the sino-aortic baroreflex was investigated before and after acute (23 patients) and chronic (23 patients) \u03b2-adrenoreceptor antagonism in patients with essential hypertension.<\/jats:p>\n               <jats:p>2. Sensitivity was inversely related to age (r = \u22120\u00b760) and systolic blood pressure (r = \u22120\u00b746); a positive relationship was noted between sensitivity and initial pulse intervals (r = 0\u00b740).<\/jats:p>\n               <jats:p>3. Sensitivity increased significantly in patients less than 40 years of age after chronic treatment. No change occurred after acute treatment or in older patients treated chronically.<\/jats:p>\n               <jats:p>4. The fall in ambulatory intra-arterial blood pressure after chronic treatment was unrelated to alteration of baroreflex sensitivity.<\/jats:p>","DOI":"10.1042\/cs0570241","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of <i>\u03b2<\/i>-Adrenoreceptor Antagonists on Sino-Aortic Baroreflex Sensitivity and Blood Pressure in Hypertensive Man"],"prefix":"10.1042","volume":"57","author":[{"given":"R. D. S.","family":"Watson","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Birmingham and East Birmingham Hospital, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Stallard","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Birmingham and East Birmingham Hospital, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. A.","family":"Littler","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Birmingham and East Birmingham Hospital, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/3\/241\/453967\/cs0570241.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/3\/241\/453967\/cs0570241.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:49:32Z","timestamp":1638478172000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/3\/241\/74824\/Effects-of-Adrenoreceptor-Antagonists-on-Sino"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0570241","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,9,1]]}}}