{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T19:30:28Z","timestamp":1726428628454},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,12,1]]},"abstract":"<jats:p>1. The chemical characteristics of the vascular connective tissue components were determined in stroke-prone (SP), stroke-resistant (SR) spontaneously hypertensive (SH) rats and normotensive Wistar-Kyoto (WK) rats.<\/jats:p>\n               <jats:p>2. The ratio of hydroxylysine to hydroxylysine plus lysine in the vascular collagen was increased in 6-month-old SP\u2014SH rats and SR\u2014SH rats as compared with WK rats.<\/jats:p>\n               <jats:p>3. An age-related increase in uronic acid and hexose content of the aorta was noted in SP\u2014SH, SR\u2014SH and WK rats. However, the increase was more prominent in SH rats, especially SP\u2014SH rats at the stages examined (11 weeks and over 8 months of age).<\/jats:p>\n               <jats:p>4. The ratio of galactosyl-hydroxylysine to glucosyl-galactosyl-hydroxylysine in the aortic collagen was decreased in 6-month-old SH rats, especially SP\u2014SH rats as compared with WK rats.<\/jats:p>\n               <jats:p>5. A relative increase in \u03b2 and \u03b3 components in aortic collagen was noted in 6-month-old SP\u2014SH rats when compared with SR\u2014SH rats.<\/jats:p>\n               <jats:p>6. The increased content of uronic acid and hexose and the structural changes of vascular collagen as demonstrated in SP\u2014SH rats might be releated to the fragility of the arterial wall and\/or to the pathogenesis of stroke-proneness.<\/jats:p>","DOI":"10.1042\/cs057035s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"35s-37s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biochemical Alterations of Connective Tissue Metabolism in the Arterial Walls of Stroke-Prone Spontaneously Hypertensive Rats"],"prefix":"10.1042","volume":"57","author":[{"given":"A.","family":"Ooshima","sequence":"first","affiliation":[{"name":"Department of Pathology, Shimane Medical University, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yamori","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shimane Medical University, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shimane Medical University, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nara","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shimane Medical University, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shimane Medical University, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/35s\/875878\/cs057035s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/35s\/875878\/cs057035s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:20:23Z","timestamp":1638480023000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/s5\/35s\/102182\/Biochemical-Alterations-of-Connective-Tissue"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":0,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs057035s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"type":"print","value":"0144-9664"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}