{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:25:53Z","timestamp":1791429953050,"version":"4.3.3"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,11,1]]},"abstract":"<jats:p>1. The determination of aldosterone-18-glucuronide (pH 1-labile aldosterone) was complemented by concomitant measurements of free urinary aldosterone and tetrahydroaldosterone in 307 patients, most of whom were hypertensive. In 38 cases (12\u00b73%) the normal, aldosterone-18-glucuronide concentration was clinically misleading, but increased free aldosterone and\/or tetrahydroaldosterone values suggested the presence of hyperaldosteronism, which in many of these cases was confirmed by elevated excretion of the possible major aldosterone precursor 18-hydroxycorticosterone (18-OH-B).<\/jats:p>\n               <jats:p>2. Of 224 patients with essential hypertension and normal or low plasma renin activity 18 had an elevated free aldosterone and\/or tetrahydroaldosterone excretion without increased aldosterone-18-glucuronide. These cases may represent early or pre-symptomatic forms of primary hyperaldosteronism. In other cases, particularly when tetrahydroaldosterone was increased alone, abnormalities of aldosterone metabolism were suspected.<\/jats:p>\n               <jats:p>3. In two out of 15 patients with primary hyperaldosteronism, aldosterone-18-glucuronide values were frequently found to be normal, although elevations were noted in other variables. However, no relation to the morphological abnormality (adenoma versus hyperplasia) was seen.<\/jats:p>","DOI":"10.1042\/cs0570409","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dissociation in the Excretion of Different Aldosterone Metabolites and Unmetabolized (\u2018Free\u2019) Aldosterone in Hypertension"],"prefix":"10.1042","volume":"57","author":[{"given":"S.","family":"Abdelhamid","sequence":"first","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik, Wiesbaden, Department of Pharmacology, University of Heidelberg, Heidelberg, and Medizinische Poliklinik Heidelberg, West Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vecsei","sequence":"additional","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik, Wiesbaden, Department of Pharmacology, University of Heidelberg, Heidelberg, and Medizinische Poliklinik Heidelberg, West Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Haack","sequence":"additional","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik, Wiesbaden, Department of Pharmacology, University of Heidelberg, Heidelberg, and Medizinische Poliklinik Heidelberg, West Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.-H.","family":"Gless","sequence":"additional","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik, Wiesbaden, Department of Pharmacology, University of Heidelberg, Heidelberg, and Medizinische Poliklinik Heidelberg, West Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Walb","sequence":"additional","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik, Wiesbaden, Department of Pharmacology, University of Heidelberg, Heidelberg, and Medizinische Poliklinik Heidelberg, West Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lichtwald","sequence":"additional","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik, Wiesbaden, Department of Pharmacology, University of Heidelberg, Heidelberg, and Medizinische Poliklinik Heidelberg, West Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fiegel","sequence":"additional","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik, Wiesbaden, Department of Pharmacology, University of Heidelberg, Heidelberg, and Medizinische Poliklinik Heidelberg, West Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/5\/409\/452029\/cs0570409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/5\/409\/452029\/cs0570409.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:06:27Z","timestamp":1638475587000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/5\/409\/72428\/Dissociation-in-the-Excretion-of-Different"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1979,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0570409","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,11,1]]}}}