{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T12:19:14Z","timestamp":1648556354518},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,12,1]]},"abstract":"<jats:p>1. Sixteen patients (11 male, five female), median age 41 years, with essential hypertension insufficiently controlled by hydrochlorothiazide (75 mg\/day; diastolic blood pressure \u2265 100 mmHg), were studied.<\/jats:p>\n               <jats:p>2. Plasma renin concentration [renin], plasma angiotensin II concentration ([ANG II]), plasma volume and exchangeable sodium (NaE) were determined, and a saralasin infusion (5\u00b74 nmol min\u22121 kg\u22121) was carried out while the patients were on thiazide alone and, in 14 cases, 3 months after addition of a \u03b2-adrenoreceptor blocker (propranolol, six, metoprolol, six, and atenolol, two patients).<\/jats:p>\n               <jats:p>3. On thiazide alone, saralasin caused a significant decrease in mean arterial blood pressure in 12 out of 16 patients. The saralasin response was closely related to pre-saralasin plasma [ANG II] (r = \u22120\u00b773, P &amp;lt; 0\u00b701). Plasma [renin] and [ANG II] were higher than normal in the group as a whole.<\/jats:p>\n               <jats:p>4. After addition of a \u03b2-adrenoreceptor blocker systolic and diastolic blood pressure decreased from 164\/109 mmHg to 136\/94 mmHg. Plasma [renin] and [ANG II] decreased by 40 and 58% respectively. At this point, saralasin caused no significant change in mean arterial pressure. No close correlation was found between plasma [renin] or [ANG II] or saralasin response on thiazide treatment and changes in blood pressure during subsequent thiazide\/\u03b2-adrenoreceptor-blocker treatment. Plasma volume and NaE did not change significantly.<\/jats:p>\n               <jats:p>5. In patients with thiazide-induced stimulation of the renin\u2014angiotensin system, addition of a \u03b2-adrenoreceptor blocker leads to suppression of the system and, at the same time, ANG II-dependence of blood pressure disappears. This contributes to the antihypertensive effect of \u03b2-adrenoreceptor blockers in this particular situation.<\/jats:p>","DOI":"10.1042\/cs057123s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"123s-125s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Angiotensin II Blockade during Combined Thiazide\u2014<i>\u03b2<\/i>-Adrenoreceptor-Blocker Treatment"],"prefix":"10.1042","volume":"57","author":[{"given":"H.","family":"Ibsen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Medical Department C, Glostrup Hospital. Medical Department C, Diakonissestiftelsen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Leth","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Medical Department C, Glostrup Hospital. Medical Department C, Diakonissestiftelsen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"McNair","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Medical Department C, Glostrup Hospital. Medical Department C, Diakonissestiftelsen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Giese","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Medical Department C, Glostrup Hospital. Medical Department C, Diakonissestiftelsen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/123s\/876030\/cs057123s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/123s\/876030\/cs057123s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:22:32Z","timestamp":1638480152000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/s5\/123s\/102407\/Angiotensin-II-Blockade-during-Combined-Thiazide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":0,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs057123s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}