{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:46:34Z","timestamp":1759481194405},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,12,1]]},"abstract":"<jats:p>1. Captopril was shown to be as effective as hydrochlorothiazide in lowering the blood pressure in patients with moderately severe essential hypertension.<\/jats:p>\n               <jats:p>2. With the combination of captopril and hydrochlorothiazide satisfactory control of blood pressure was maintained over 8 months.<\/jats:p>\n               <jats:p>3. Inhibition of angiotensin converting enzyme by captopril in man was associated with falls in plasma angiotensin II and urinary aldosterone and rises in angiotensin I and plasma renin.<\/jats:p>\n               <jats:p>4. No change in venous concentrations of bradykinin could be demonstrated during therapy.<\/jats:p>\n               <jats:p>5. Captopril attenuated the hyperaldosteronism and hypokalaemia associated with diuretic therapy.<\/jats:p>","DOI":"10.1042\/cs057135s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"135s-138s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hormonal Changes with Long-Term Converting-Enzyme Inhibition by Captopril in Essential Hypertension"],"prefix":"10.1042","volume":"57","author":[{"given":"P. G.","family":"Matthews","sequence":"first","affiliation":[{"name":"Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. P.","family":"McGrath","sequence":"additional","affiliation":[{"name":"Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. I.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/135s\/876082\/cs057135s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/135s\/876082\/cs057135s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:23:20Z","timestamp":1638480200000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/s5\/135s\/102495\/Hormonal-Changes-with-Long-Term-Converting-Enzyme"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":0,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs057135s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}