{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T05:04:32Z","timestamp":1697864672484},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,12,1]]},"abstract":"<jats:p>1. Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values, and (c) brisk initial increases in plasma 18-hydroxydeoxycorticosterone and corticosterone concentrations that fall to 20\u201368% of peak values 30 h thereafter.<\/jats:p>\n               <jats:p>2. Dexamethasone (8 mg\/day, orally) treatment for 2 days in man permits a greater postural increase in plasma aldosterone and 18-hydroxycorticosterone concentrations. A dampening effect of ACTH is suggested.<\/jats:p>\n               <jats:p>3. An ACTH-initiated inhibition of 11\u03b2- and 18-hydroxylation is proposed to be operative in regulation of mineralocorticoid hormones.<\/jats:p>","DOI":"10.1042\/cs057307s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"307s-311s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adrenocorticotropin Inhibition of Mineralocorticoid Hormone Production"],"prefix":"10.1042","volume":"57","author":[{"given":"E. G.","family":"Biglieri","sequence":"first","affiliation":[{"name":"Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Chang","sequence":"additional","affiliation":[{"name":"Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hirai","sequence":"additional","affiliation":[{"name":"Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Brust","sequence":"additional","affiliation":[{"name":"Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Rost","sequence":"additional","affiliation":[{"name":"Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schambelan","sequence":"additional","affiliation":[{"name":"Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/307s\/875986\/cs057307s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/307s\/875986\/cs057307s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:21:27Z","timestamp":1638480087000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/s5\/307s\/102305\/Adrenocorticotropin-Inhibition-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":0,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs057307s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}