{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T03:51:53Z","timestamp":1648957913301},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,12,1]]},"abstract":"<jats:p>1. Blood pressure, systemic haemodynamics, plasma volume, renin and aldosterone were measured during placebo treatment and after 1, 4 and 12 weeks of hydrochlorothiazide in 13 patients with uncomplicated essential hypertension. Nine of these patients were also studied after 24 and 36 weeks of treatment.<\/jats:p>\n               <jats:p>2. Mean arterial pressure was lowered significantly during hydrochlorothiazide treatment. In seven patients the fall in mean arterial pressure was greater than 10% (responders); four of these were studied for 36 weeks. The remainder were considered non-responders.<\/jats:p>\n               <jats:p>3. Hydrochlorothiazide lowered cardiac output. The maximal decrease was observed after 12 weeks of treatment (P &amp;lt; 0\u00b701). In responders this was followed by a return to pretreatment values and a significant decrease in total peripheral resistance, whereas in non-responders cardiac output remained reduced and total peripheral resistance was permanently elevated.<\/jats:p>\n               <jats:p>4. Changes in plasma volume, renin and aldosterone were not significantly different in responders and non-responders although non-responders tended to show a greater degree of plasma volume depletion and a more pronounced increase in plasma aldosterone.<\/jats:p>\n               <jats:p>5. Thus it is unlikely that the initial decrease in cardiac output is an important determinant of the long-term haemodynamic effect of thiazide diuretics.<\/jats:p>","DOI":"10.1042\/cs057359s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"359s-362s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Haemodynamics during Long-Term Thiazide Treatment in Essential Hypertension: Differences between Responders and Non-Responders"],"prefix":"10.1042","volume":"57","author":[{"given":"P.","family":"Van Brummelen","sequence":"first","affiliation":[{"name":"Department of Nephrology, University Hospital, Leiden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Man In 't","family":"Veld","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A. D. H.","family":"Schalekamp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/359s\/876002\/cs057359s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/359s\/876002\/cs057359s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:21:30Z","timestamp":1638480090000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/s5\/359s\/102312\/Haemodynamics-during-Long-Term-Thiazide-Treatment"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":0,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs057359s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}