{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:51:58Z","timestamp":1756993918384},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,12,1]]},"abstract":"<jats:p>1. In hypertension, the \u03b2-adrenoreceptor-blocker-withdrawal syndrome comprises tachycardia, sweating, tremor and general malaise, symptoms resembling thyrotoxicosis.<\/jats:p>\n               <jats:p>2. The effect of abrupt cessation of propranolol on serum concentrations of thyroxine (T4) and tri-iodothyronine (T3) was therefore investigated in five patients with uncomplicated essential hypertension, treated with propranolol in doses from 160 to 480 mg\/day.<\/jats:p>\n               <jats:p>3. Four of the five patients developed one or more of the above-mentioned symptoms within 2\u20136 days after withdrawal of propranolol.<\/jats:p>\n               <jats:p>4. A mean relative increase in serum free T3 of 51% (range 22\u201374%) was found in these four patients on the day of onset of symptoms.<\/jats:p>\n               <jats:p>5. The increase in free T3 in the five patients correlated positively with total serum propranolol on the last day the drug was given (r = 0\u00b791, 2P = 0\u00b703).<\/jats:p>\n               <jats:p>6. As an increase in T3 was found only in patients suffering the withdrawal syndrome, and was maximal the day the symptoms appeared, despite a variation in time of onset from 2 to 6 days, it is suggested that the \u03b2-adrenoreceptor-blocker-withdrawal syndrome, at least partially, is caused by a rebound increased production of T3, induced by the well-known inhibition of the monodeiodination of T4 to T3 during \u03b2-adrenoreceptor blockade.<\/jats:p>\n               <jats:p>7. This assumption may explain the clinical symptoms and the reported transient increased \u03b2-adrenoreceptor sensitivity with unchanged serum concentrations of catecholamines.<\/jats:p>","DOI":"10.1042\/cs057417s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"417s-420s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Pathogenesis of Propranolol-Withdrawal Syndrome in Essential Hypertension"],"prefix":"10.1042","volume":"57","author":[{"given":"B. \u00d8.","family":"Kristensen","sequence":"first","affiliation":[{"name":"Medical Department P, Randers City Hospital, University Hospital of Aarhus, Randers, Medical Department B, Rigshospitalet, Copenhagen"},{"name":"Department of Pharmacology, University of Copenhagen, and Second University Clinic of Internal Medicine, University of Aarhus, Kommunehospitalet, \u00c5rhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVA","family":"Steiness","sequence":"additional","affiliation":[{"name":"Medical Department P, Randers City Hospital, University Hospital of Aarhus, Randers, Medical Department B, Rigshospitalet, Copenhagen"},{"name":"Department of Pharmacology, University of Copenhagen, and Second University Clinic of Internal Medicine, University of Aarhus, Kommunehospitalet, \u00c5rhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Weeke","sequence":"additional","affiliation":[{"name":"Medical Department P, Randers City Hospital, University Hospital of Aarhus, Randers, Medical Department B, Rigshospitalet, Copenhagen"},{"name":"Department of Pharmacology, University of Copenhagen, and Second University Clinic of Internal Medicine, University of Aarhus, Kommunehospitalet, \u00c5rhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/417s\/876042\/cs057417s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/417s\/876042\/cs057417s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:22:57Z","timestamp":1638480177000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/s5\/417s\/102455\/The-Pathogenesis-of-Propranolol-Withdrawal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":0,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs057417s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}