{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:26:01Z","timestamp":1760646361576},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,12,1]]},"abstract":"<jats:p>1. The properties of a new antihypertensive agent, SK&amp;F 92657, dl-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine, have been studied.<\/jats:p>\n               <jats:p>2. The compound caused a sustained fall in blood pressure in several species as a result of precapillary vasodilatation, particularly in the renal and coronary vasculatures.<\/jats:p>\n               <jats:p>3. The \u03b2-adrenoreceptor-blocking actions of SK&amp;F 92657 prevent reflex cardiac stimulation.<\/jats:p>","DOI":"10.1042\/cs057433s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"433s-436s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["SK&amp;F 92657, a Novel Antihypertensive Acting by Precapillary Vasodilatation and \u03b2-Adrenoreceptor Blockade"],"prefix":"10.1042","volume":"57","author":[{"given":"E. M.","family":"Taylor","sequence":"first","affiliation":[{"name":"The Research Institute, Smith Kline and French Research Limited, Welwyn Garden City, Herts., U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Roe","sequence":"additional","affiliation":[{"name":"The Research Institute, Smith Kline and French Research Limited, Welwyn Garden City, Herts., U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Slater","sequence":"additional","affiliation":[{"name":"The Research Institute, Smith Kline and French Research Limited, Welwyn Garden City, Herts., U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/433s\/875880\/cs057433s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/433s\/875880\/cs057433s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:20:24Z","timestamp":1638480024000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/s5\/433s\/102180\/SK-amp-F-92657-a-Novel-Antihypertensive-Acting-by"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":0,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs057433s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}