{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T16:28:47Z","timestamp":1699720127699},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,1,1]]},"abstract":"<jats:p>1. Five normal subjects were studied under metabolic conditions on a controlled sodium and potassium intake.<\/jats:p>\n               <jats:p>2. Plasma and urine free dopamine concentrations were measured in these subjects before, during and after 5 days administration of fludrocortisone (0\u00b72 mg twice daily).<\/jats:p>\n               <jats:p>3. Urine free dopamine showed a tendency to fall during the early phase of fludrocortisone administration and then rose towards normal.<\/jats:p>\n               <jats:p>4. In a patient with primary hyperaldosteronism there was no evidence of increased renal production of dopamine. Urine dopamine fell when plasma renin activity rose as a result of spironolactone administration (200 mg three times a day for 5 days).<\/jats:p>\n               <jats:p>5. If renal dopamine has a role in mineralocorticoid \u2018escape\u2019 then it may be permissive only. The mechanisms of control of dopamine production could include tubular sodium concentration, tubular chloride concentration and intrarenal renin activity.<\/jats:p>","DOI":"10.1042\/cs0580077","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"77-82","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of Mineralocorticoid Administration on Urine Free Dopamine in Man"],"prefix":"10.1042","volume":"58","author":[{"given":"N. S.","family":"Oates","sequence":"first","affiliation":[{"name":"Department of Pharmacology, The University of Leeds, and Department of Medicine, Leeds General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The University of Leeds, and Department of Medicine, Leeds General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The University of Leeds, and Department of Medicine, Leeds General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/1\/77\/452106\/cs0580077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/1\/77\/452106\/cs0580077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:08:37Z","timestamp":1638475717000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/58\/1\/77\/72497\/The-Effect-of-Mineralocorticoid-Administration-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0580077","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1,1]]}}}