{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:05:28Z","timestamp":1765667128928},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,3,1]]},"abstract":"<jats:p>1. The activities and subcellular distribution of enzymes implicated in the protection of cells from free-radical mediated damage were determined in liver biopsy specimens from control and iron-overloaded patients.<\/jats:p>\n               <jats:p>2. There was a small but insignificant decrease in the activity of glutathione reductase in patients with secondary iron overload due to multiple transfusion therapy for thalassaemia major.<\/jats:p>\n               <jats:p>3. The activities of superoxide dismutase, catalase and glutathione peroxidase were similar in both patient groups.<\/jats:p>\n               <jats:p>4. Subcellular fractionation studies indicated a major cytosolic localization of these enzymes with a minor mitochondrial component. The relative proportions of the enzymes in the two locations was similar in both control and iron-overloaded patients.<\/jats:p>\n               <jats:p>5. Approximately 80% of the hepatic glutathione was present in the reduced form in both patient groups and it is concluded that although free-radical mediated damage might be implicated in the pathogenesis of tissue damage due to iron overload no significant defect in these protective mechanisms can be demonstrated.<\/jats:p>","DOI":"10.1042\/cs0580211","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"211-219","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Activities of Some Free-Radical Scavenging Enzymes and Glutathione Concentrations in Human and Rat Liver and their Relationship to the Pathogenesis of Tissue Damage in Iron Overload"],"prefix":"10.1042","volume":"58","author":[{"given":"Clare","family":"Selden","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London and Division of Clinical Cell Biology, Clinical Research Centre, Harrow, Middlesex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Seymour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London and Division of Clinical Cell Biology, Clinical Research Centre, Harrow, Middlesex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, London and Division of Clinical Cell Biology, Clinical Research Centre, Harrow, Middlesex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/3\/211\/452108\/cs0580211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/3\/211\/452108\/cs0580211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:03:52Z","timestamp":1638475432000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/58\/3\/211\/72359\/Activities-of-Some-Free-Radical-Scavenging-Enzymes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0580211","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,3,1]]}}}