{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:07:24Z","timestamp":1695575244360},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,4,1]]},"abstract":"<jats:p>1. d-Galactosamine-HCl induces toxic hepatitis in the rat and was used as a model to study some aspects of iron metabolism during liver cell damage. Some changes in iron metabolism were similar to those encountered in human acute viral hepatitis.<\/jats:p>\n               <jats:p>2. During the first 3 days of liver cell damage induced by galactosamine, liver depot iron and especially ferritin iron decreased by approximately 20%. Plasma ferritin rose, with a peak mean value which was approximately 20 times the concentration measured in normal rats.<\/jats:p>\n               <jats:p>3. During the acute phase, plasma ferritin did not accurately reflect the change in the level of liver depot iron.<\/jats:p>\n               <jats:p>4. During and after the acute phase, liver depot iron increased after an initial decrease. The non-ferritin depot iron fraction was elevated approximately 75% compared with the value in normal rats. This increase in non-ferritin iron was probably caused by increased erythrocyte catabolism in the liver and recapture followed by catabolism of liver ferritin that had leaked into the blood.<\/jats:p>","DOI":"10.1042\/cs0580321","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"321-325","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rat Liver Storage Iron and Plasma Ferritin during d-Galactosamine-Hcl-Induced Hepatitis"],"prefix":"10.1042","volume":"58","author":[{"given":"F. M. J.","family":"Zuyderhoudt","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Medicine, University of Amsterdam, Wilhelmina Gasthuis, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. G. A.","family":"J\u00f6rning","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Medicine, University of Amsterdam, Wilhelmina Gasthuis, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"De Haan","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Medicine, University of Amsterdam, Wilhelmina Gasthuis, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Samson","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Amsterdam, Wilhelmina Gasthuis, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Van Gool","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Medicine, University of Amsterdam, Wilhelmina Gasthuis, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/4\/321\/452221\/cs0580321.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/4\/321\/452221\/cs0580321.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:04:43Z","timestamp":1638475483000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/58\/4\/321\/72392\/Rat-Liver-Storage-Iron-and-Plasma-Ferritin-during"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0580321","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,4,1]]}}}