{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:19:36Z","timestamp":1761059976705},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,6,1]]},"abstract":"<jats:p>1. Direct radioligand\u2014binding techniques have been used to characterize and quantify adrenoreceptors in human peripheral lung tissue removed at thoracotomy from ten patients, nine of whom had evidence of obstructive airways disease.<\/jats:p>\n               <jats:p>2. [3H]Dihydroalprenolol was used to characterize \u03b2\u2013adrenoreceptor sites and [3H]prazosin to identify \u03b1\u2013adrenoreceptor sites. Binding of both ligands showed saturability, high affinity, rapid kinetics, reversibility and stereospecificity. The rank order of agonists and antagonists inhibiting specific binding correlated well with known physiological potencies. Specificity of [3H]dihydroal-prenolol binding suggested that the population of lung \u03b2\u2013adrenoreceptors is predominantly of the \u03b22 subtype.<\/jats:p>","DOI":"10.1042\/cs0580457","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"457-461","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Human Lung Adrenoreceptors Studied by Radioligand Binding"],"prefix":"10.1042","volume":"58","author":[{"given":"P. J.","family":"Barnes","sequence":"first","affiliation":[{"name":"1Department of Clinical Pharmacology, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Karliner","sequence":"additional","affiliation":[{"name":"2Department of Clinical Pharmacology, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. T.","family":"Dollery","sequence":"additional","affiliation":[{"name":"3Department of Clinical Pharmacology, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/6\/457\/452413\/cs0580457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/6\/457\/452413\/cs0580457.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:07:39Z","timestamp":1638475659000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/58\/6\/457\/72461\/Human-Lung-Adrenoreceptors-Studied-by-Radioligand"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1980,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0580457","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,6,1]]}}}