{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:40:49Z","timestamp":1756993249398},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,6,1]]},"abstract":"<jats:p>1. The effect of chronic bile-duct ligation on systemic and renal haemodynamics and on the capacity to dilute the urine was studied in conscious rats. Sham-operated rats served as controls.<\/jats:p>\n               <jats:p>2. In the rats with bile-duct ligation, the maximal urinary diluting capacity was impaired, despite an expanded plasma volume, a normal mean arterial pressure and cardiac output, and normal intrarenal determinants of water excretion including distal delivery of fluid and function of the diluting segment.<\/jats:p>\n               <jats:p>3. In contrast, maximal urinary dilution capacity was intact in rats with congenital central diabetes insipidus and chronic bile-duct ligation.<\/jats:p>\n               <jats:p>4. It is concluded that the defect in urinary dilution in rats with chronic bile-duct ligation is dependent on antidiuretic hormone.<\/jats:p>","DOI":"10.1042\/cs0580493","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"493-500","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Role of Antidiuretic Hormone in Impaired Urinary Dilution Associated with Chronic Bile-Duct Ligation"],"prefix":"10.1042","volume":"58","author":[{"given":"O. S.","family":"Better","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Colorado Medical Center, and Department of Pathology, Veterans Administration Hospital, Denver, Colorado, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Aisenbrey","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical Center, and Department of Pathology, Veterans Administration Hospital, Denver, Colorado, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Berl","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical Center, and Department of Pathology, Veterans Administration Hospital, Denver, Colorado, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical Center, and Department of Pathology, Veterans Administration Hospital, Denver, Colorado, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. A.","family":"Handelman","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical Center, and Department of Pathology, Veterans Administration Hospital, Denver, Colorado, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Linas","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical Center, and Department of Pathology, Veterans Administration Hospital, Denver, Colorado, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Guggenheim","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical Center, and Department of Pathology, Veterans Administration Hospital, Denver, Colorado, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Schrier","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical Center, and Department of Pathology, Veterans Administration Hospital, Denver, Colorado, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/6\/493\/452433\/cs0580493.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/58\/6\/493\/452433\/cs0580493.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:07:36Z","timestamp":1638475656000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/58\/6\/493\/72459\/Role-of-Antidiuretic-Hormone-in-Impaired-Urinary"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1980,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0580493","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,6,1]]}}}