{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:54:32Z","timestamp":1771628072521,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,11,1]]},"abstract":"<jats:p>1. The metabolism of the major proteins of plasma high-density lipoprotein (HDL), apoproteins AI and AII, have been studied in 10 normotriglyceridaemic subjects and in 11 hypertriglyceridaemic subjects (plasma triglyceride 4.5\u201325 mmol\/l) by kinetic analysis of the plasma specific radioactivity versus time curves of the apoproteins after intravenous injection of autologous 125I-labelled high-density lipoprotein.<\/jats:p>\n               <jats:p>2. The specific radioactivity versus time curves of both apoproteins (followed for 14 days) were bi-exponential in all subjects.<\/jats:p>\n               <jats:p>3. The plasma apoprotein AI and AII concentrations were significantly lower in the hypertriglyceridaemic subjects than in the normotriglyceridaemic subjects. Kinetic analysis showed that this was associated with a lower rate of synthesis of apoprotein AI (P &amp;lt; 0.01) and a higher fractional catabolic rate of apoprotein AII (P &amp;lt; 0.01) in the hypertriglyceridaemic group.<\/jats:p>\n               <jats:p>4. There were no significant differences between the two groups in the synthetic rate of apoprotein AII, the fractional catabolic rate of apoprotein AI or the intravascular\/extravascular distributions of the apoproteins.<\/jats:p>\n               <jats:p>5. Thus hypertriglyceridaemia appears to be frequently associated with divergent abnormalities of the metabolism of the major high-density lipoprotein apoproteins.<\/jats:p>","DOI":"10.1042\/cs0590359","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:24Z","timestamp":1438943784000},"page":"359-367","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Plasma High-Density Lipoprotein Metabolism in Subjects with Primary Hypertriglyceridaemia: Altered Metabolism of Apoproteins AI and AII"],"prefix":"10.1042","volume":"59","author":[{"given":"S. N.","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology and Metabolic Disorders. St Thomas' Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Magill","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology and Metabolic Disorders. St Thomas' Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology and Metabolic Disorders. St Thomas' Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology and Metabolic Disorders. St Thomas' Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/5\/359\/452378\/cs0590359.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/5\/359\/452378\/cs0590359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:09:29Z","timestamp":1638475769000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/59\/5\/359\/72531\/Plasma-High-Density-Lipoprotein-Metabolism-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1980,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0590359","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,11,1]]}}}