{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T09:52:45Z","timestamp":1648893165906},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,12,1]]},"abstract":"<jats:p>1. Unilateral renal artery constriction in rats maintained on a sodium-deplete, but not sodium-replete, diet induced an augmented acute vasodepressor response to kininase II inhibition produced by an intravenous injection of the dipeptidyl carboxypeptidase inhibitor captopril (250 \u03bcg) during continuous saralasin-induced angiotensin II blockade (10 \u03bcg\/min). Dietary sodium restriction alone in sham-operated rats had no effect.<\/jats:p>\n               <jats:p>2. Acute bilateral adrenalectomy (18-24 h) did not preclude the demonstration of an augmented response to kininase II inhibition in sodium-depleted rats with benign two-kidney, one-clip hypertension. Neither did chronic administration of deoxycorticosterone acetate in intact rats elicit an augmented response.<\/jats:p>\n               <jats:p>3. The augmented acute vasodepressor response to kininase II inhibition in sodium-depleted rats with benign two-kidney, one-clip hypertension is probably due to bradykinin potentiation and secondary to an increased activity of the kallikrein-kinin system. The mechanism responsible for this apparent increase is not known, but neither hyperangiotensinemia nor hyperaldosteronism seems to play a role.<\/jats:p>","DOI":"10.1042\/cs059175s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:24Z","timestamp":1438943784000},"page":"175s-178s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Variations in Sodium Intake on the Acute Vasodepressor Response to Kininase II Inhibition in Rats with Mild Two-Kidney, One-Clip Hypertension"],"prefix":"10.1042","volume":"59","author":[{"given":"T.","family":"Kushiro","sequence":"first","affiliation":[{"name":"Hypertension Service, Cedars-Sinai Medical Center, Los Angeles, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Hypertension Service, Cedars-Sinai Medical Center, Los Angeles, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Girolami","sequence":"additional","affiliation":[{"name":"Hypertension Service, Cedars-Sinai Medical Center, Los Angeles, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Gassia","sequence":"additional","affiliation":[{"name":"Hypertension Service, Cedars-Sinai Medical Center, Los Angeles, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Hypertension Service, Cedars-Sinai Medical Center, Los Angeles, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/175s\/876375\/cs059175s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/175s\/876375\/cs059175s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:23:36Z","timestamp":1638480216000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/59\/s6\/175s\/102492\/Effects-of-Variations-in-Sodium-Intake-on-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12,1]]},"references-count":0,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[1980,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs059175s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1980,12,1]]}}}