{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:00:18Z","timestamp":1770487218986,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,12,1]]},"abstract":"<jats:p>1. We have investigated the function of the Na+-K+ pump in the erythrocytes of patients with various types of hypertension by measuring the activity of ouabain-sensitive Na+-K+-dependent ATPase and ouabain-insensitive ATPase in the erythrocyte ghosts of these patients.<\/jats:p>\n               <jats:p>2. Mean Na+-K+-ATPase activity was increased threefold in six patients with Cushing's syndrome and hypertension (0.985 \u00b1 sd 0.288 \u03bcmol of phosphate h\u22121 mg\u22121) compared with that in 49 control subjects (0.334 \u00b1 0.147 \u03bcmol of phosphate h\u22121 mg\u22121) (P&amp;lt;0.0025), but not in four patients with primary aldosteronism (0.278 \u00b1 0.108 \u03bcmol of phosphate h\u22121 mg\u22121).<\/jats:p>\n               <jats:p>3. Na+-K+-ATPase activity slightly exceeded the control range in 57 patients with primary hypertension (0.410 \u00b1 0.245 \u03bcmol of phosphate h\u22121 mg\u22121; P&amp;lt;0.025) and in 12 patients with renal hypertension (0.475 \u00b1 0.250 \u03bcmol of phosphate h\u22121 mg\u22121) (P&amp;lt;0.025).<\/jats:p>\n               <jats:p>4. There was no difference in ouabain-insensitive ATPase between the controls and the different types of hypertension.<\/jats:p>\n               <jats:p>5. The data support the hypothesis of an activation of the Na+ pump in patients with glucocorticoid excess. This helps to explain previous observations of a redistribution of sodium and water to the extracellular compartment in experimental glucocorticoid-induced hypertension.<\/jats:p>","DOI":"10.1042\/cs059183s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:24Z","timestamp":1438943784000},"page":"183s-185s","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sodium\u2014Potassium-Dependent ATPase Activity in Erythrocyte Ghosts of Patients with Primary and Secondary Hypertension"],"prefix":"10.1042","volume":"59","author":[{"given":"G.","family":"Wambach","sequence":"first","affiliation":[{"name":"Department of Medicine II, University of Cologne, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Helber","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University of Cologne, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bounner","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University of Cologne, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Hummerich","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University of Cologne, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Konrads","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University of Cologne, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University of Cologne, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/183s\/876413\/cs059183s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/183s\/876413\/cs059183s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:23:51Z","timestamp":1638480231000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/59\/s6\/183s\/102555\/Sodium-Potassium-Dependent-ATPase-Activity-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12,1]]},"references-count":0,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[1980,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs059183s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1980,12,1]]}}}