{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:09:32Z","timestamp":1787004572286,"version":"build-2736575974"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,12,1]]},"abstract":"<jats:p>1. In the autoperfused hind limb of the dog prazosin (10\u03bcg\/kg intravenously) markedly antagonized responses to lumbar sympathetic stimulation, whereas responses to injected nor-adrenaline were largely unaffected.<\/jats:p>\n                  <jats:p>2. In \u03b2-adrenoreceptor- and ganglion-blocked animals, the hind limb pressor responses to phenylephrine were antagonized to a greater degree by prazosin than responses to injected noradrenaline.<\/jats:p>\n                  <jats:p>3. Rauwolscine, a selective \u03b12-adrenoreceptor-blocking agent, antagonized responses to the \u03b12-adrenoreceptor agonist guanabenz, but not those to phenylephrine.<\/jats:p>\n                  <jats:p>4. Hind limb pressor responses to noradrenaline were significantly inhibited by rauwolscine and further reduced by prazosin.<\/jats:p>\n                  <jats:p>5. These results demonstrate that in this vascular bed \u03b11- and \u03b12-adrenoreceptors are located postsynaptically. Furthermore the results suggest that neuronally released noradrenaline acts mainly upon \u03b11-adrenoreceptors, whereas exogenous noradrenaline acts upon \u03b11- and \u03b12-adrenoreceptors.<\/jats:p>\n                  <jats:p>6. It is suggested that this selectivity of prazosin in blocking the vasoconstriction to neuronally-released noradrenaline may in part explain the effectiveness of this drug as an antihypertensive agent.<\/jats:p>","DOI":"10.1042\/cs059225s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:36:24Z","timestamp":1438929384000},"page":"225s-228s","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Presence of Postsynaptic \u03b12-Adrenoreceptors of Predominantly Extrasynaptic Location in the Vascular Smooth Muscle of the Dog Hind Limb"],"prefix":"10.1042","volume":"59","author":[{"given":"S. Z.","family":"Langer","sequence":"first","affiliation":[{"name":"Department of Biology Synth\u00e9labo L.E.R.S., Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Massingham","sequence":"additional","affiliation":[{"name":"Department of Biology Synth\u00e9labo L.E.R.S., Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. B.","family":"Shepperson","sequence":"additional","affiliation":[{"name":"Department of Biology Synth\u00e9labo L.E.R.S., Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/225s\/876367\/cs059225s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/225s\/876367\/cs059225s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T16:23:00Z","timestamp":1638462180000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/59\/s6\/225s\/102463\/Presence-of-Postsynaptic-2-Adrenoreceptors-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12,1]]},"references-count":0,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[1980,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs059225s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1980,12,1]]}}}