{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:56:47Z","timestamp":1715540207365},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,12,1]]},"abstract":"<jats:p>1. ACTH administration (20 \u03bcg day\u22121 kg\u22121) to sheep produces hypertension associated with a raised cardiac output and hypokalaemia.<\/jats:p>\n               <jats:p>2. The aim of the present experiments was to detail the haemodynamic changes associated with restoration of the extracellular potassium concentration in sheep with ACTH-induced hypertension.<\/jats:p>\n               <jats:p>3. After 7 days of ACTH treatment potassium chloride (10 mmol\/h) was infused for 3 days to restore plasma [K+] to the pre-ACTH value.<\/jats:p>\n               <jats:p>4. ACTH reduced plasma [K+] from 4.4 \u00b1 0.1 to 3.2 \u00b1 0.2 mmol\/l but 3 days of potassium chloride infusion returned plasma [K+] to 4.3 \u00b1 0.2 mmol\/l.<\/jats:p>\n               <jats:p>5. ACTH increased mean arterial pressure from 67 \u00b1 2 to 88 \u00b1 1 mmHg in the first 7 days and it remained elevated during potassium chloride infusion (91 \u00b1 5 mmHg on day 10).<\/jats:p>\n               <jats:p>6. Cardiac output rose with 7 days ACTH treatment from 4.9 \u00b1 0.2 to 6.0 \u00b1 0.6 l\/min but fell progressively with potassium chloride infusion to 4.9 \u00b1 0.3 l\/min on day 10.<\/jats:p>\n               <jats:p>7. These studies suggest that potassium status or extracellular [K+] may play a role in determining the haemodynamic profile associated with steroid-induced hypertension.<\/jats:p>","DOI":"10.1042\/cs059373s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:24Z","timestamp":1438943784000},"page":"373s-376s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Haemodynamic Effects of Increasing Extracellular Potassium Concentration in ACTH-Induced Hypertension in Sheep"],"prefix":"10.1042","volume":"59","author":[{"given":"B. A.","family":"Scoggins","sequence":"first","affiliation":[{"name":"University of Tennessee, Memphis, Tennessee, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Coghlan","sequence":"additional","affiliation":[{"name":"University of Tennessee, Memphis, Tennessee, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Denton","sequence":"additional","affiliation":[{"name":"University of Tennessee, Memphis, Tennessee, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"University of Tennessee, Memphis, Tennessee, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. F.","family":"Graham","sequence":"additional","affiliation":[{"name":"University of Tennessee, Memphis, Tennessee, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Mason","sequence":"additional","affiliation":[{"name":"University of Tennessee, Memphis, Tennessee, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. G.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/373s\/876409\/cs059373s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/373s\/876409\/cs059373s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:23:27Z","timestamp":1638480207000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/59\/s6\/373s\/102508\/Haemodynamic-Effects-of-Increasing-Extracellular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12,1]]},"references-count":0,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[1980,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs059373s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1980,12,1]]}}}