{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T15:54:16Z","timestamp":1699718056372},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,12,1]]},"abstract":"<jats:p>1. The antihypertensive effect of the new drug, SKF 92 657, a hydrazinopyridazine derivative, possessing both \u03b2-adrenoreceptor-blocking and vasodilating properties, was investigated in essential hypertension.<\/jats:p>\n               <jats:p>2. Single oral doses of 1.0 or 2.0 mg\/kg did not produce any consistent decrease in blood pressure; 4.0 mg\/kg was the threshold dose for a mild but not significant blood pressure reduction, whereas 8.0 mg\/kg caused a significant and marked blood pressure decrease without clinically relevant changes in heart rate.<\/jats:p>\n               <jats:p>3. Continued administration of the drug for 7 days induced a significant and uniform reduction in blood pressure without tachycardia. The increase in systolic blood pressure and in heart rate caused by dynamic exercise was left unaffected by the drug.<\/jats:p>","DOI":"10.1042\/cs059461s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:24Z","timestamp":1438943784000},"page":"461s-463s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dose-Response Curve and Time Course of the Antihypertensive Effect of SKF 92 657, a <i>\u03b2<\/i>-Receptor-Blocking and Vasodilating Compound"],"prefix":"10.1042","volume":"59","author":[{"given":"G.","family":"Leonetti","sequence":"first","affiliation":[{"name":"Istituto di Ricerche Cardiovascolari, Istituto di Patologia Medica I, Universit\u00e0 di Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Terzoli","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Cardiovascolari, Istituto di Patologia Medica I, Universit\u00e0 di Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Sala","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Cardiovascolari, Istituto di Patologia Medica I, Universit\u00e0 di Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bianchini","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Cardiovascolari, Istituto di Patologia Medica I, Universit\u00e0 di Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zanchetti","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Cardiovascolari, Istituto di Patologia Medica I, Universit\u00e0 di Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/461s\/876399\/cs059461s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/59\/s6\/461s\/876399\/cs059461s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:23:26Z","timestamp":1638480206000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/59\/s6\/461s\/102504\/Dose-Response-Curve-and-Time-Course-of-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12,1]]},"references-count":0,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[1980,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs059461s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1980,12,1]]}}}