{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:06:13Z","timestamp":1773284773480,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,1,1]]},"abstract":"<jats:p>1. Erythrocytes with membrane abnormalities seen on interference contrast microscopy (\u2018pitted erythrocytes\u2019) were counted in venous blood samples from patients with treated coeliac disease and dermatitis herpetiformis, and from control subjects and patients who had had an elective splenectomy.<\/jats:p>\n               <jats:p>2. The percentage of \u2018pitted erythrocytes\u2019 was compared with the 99mTc-labelled heat-damaged erythrocyte clearance, and with the splenic size computed from scintiscans.<\/jats:p>\n               <jats:p>3. There was a significant correlation between percentage \u2018pitted erythrocytes\u2019 and the above methods of measuring splenic function and size. Increase in the percentage of \u2018pitted erythrocytes\u2019 above the control range indicated splenic hypofunction.<\/jats:p>\n               <jats:p>4. The number of coeliac patients with percentage \u2018pitted erythrocytes\u2019 above the control range increased with increasing age at which they started a gluten-free diet.<\/jats:p>\n               <jats:p>5. Counting of \u2018pitted erythrocytes\u2019 is a simple and sensitive method of assessing splenic hypofunction in treated coeliac disease. It avoids radiation exposure, and is applicable to all ages and repeatable without risk.<\/jats:p>\n               <jats:p>6. The incidence of splenic hypofunction in coeliac patients may be related to the duration of untreated disease.<\/jats:p>","DOI":"10.1042\/cs0600109","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:37:56Z","timestamp":1438943876000},"page":"109-113","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Simple Method of Assessing Splenic Function in Coeliac Disease"],"prefix":"10.1042","volume":"60","author":[{"given":"G. R.","family":"Corazza","sequence":"first","affiliation":[{"name":"Department of Medicine, St James's University Hospital, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"Bullen","sequence":"additional","affiliation":[{"name":"Department of Medicine, St James's University Hospital, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Medicine, St James's University Hospital, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Medicine, St James's University Hospital, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Losowsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, St James's University Hospital, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/60\/1\/109\/503362\/cs0600109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/60\/1\/109\/503362\/cs0600109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:14:30Z","timestamp":1638476070000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/60\/1\/109\/72672\/Simple-Method-of-Assessing-Splenic-Function-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0600109","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1,1]]}}}