{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:43:39Z","timestamp":1758278619904},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,3,1]]},"abstract":"<jats:p>1. Plasma membranes were prepared from parathyroid adenomas in patients with primary hyperparathyroidism and from hyperplastic glands obtained from patients with chronic renal insufficiency. The basal and isoproterenol- or sodium fluoride-stimulated adenylate cyclase activities were measured in membranes in the presence of several vitamin D3 metabolites.<\/jats:p>\n               <jats:p>2. 24,25-Dihydroxycholecalciferol (10 and 1000 pmol\/l) decreased isoproterenol- and sodium fluoride-stimulated adenylate cyclase activities in membranes prepared from parathyroid glands. 1,25-Dihydroxycholecalciferol (1000 pmol\/l) inhibited the isoproterenol-stimulated adenylate cyclase activity. 25-Hydroxycholecalciferol and vitamin D3 had no effect on adenylate cyclase activities. Basal adenylate cyclase activity was not affected by any of the vitamin D3 metabolites tested.<\/jats:p>\n               <jats:p>3. These results indicate that 24,25-dihydroxycholecalciferol inhibits the isoproterenol- and sodium fluoride-stimulated adenylate cyclase activities in parathyroid tissues. Such an inhibition could explain the very rapid decrease in parathyroid hormone secretion after 24,25-dihydroxycholecalciferol administration that has been previously reported.<\/jats:p>","DOI":"10.1042\/cs0600339","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:37:56Z","timestamp":1438943876000},"page":"339-341","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human Parathyroid Gland Adenylate Cyclase Activity: Inhibition by 24,25-Dihydroxycholecalciferol <i>in vitro<\/i>"],"prefix":"10.1042","volume":"60","author":[{"given":"J. F.","family":"Cloix","sequence":"first","affiliation":[{"name":"INSERM U.90, H\u00f4pital Necker, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ulmann","sequence":"additional","affiliation":[{"name":"INSERM U.90, H\u00f4pital Necker, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Monet","sequence":"additional","affiliation":[{"name":"INSERM S.C.R.4, H\u00f4pital Necker, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Funck-Brentano","sequence":"additional","affiliation":[{"name":"INSERM U.90, H\u00f4pital Necker, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/60\/3\/339\/452750\/cs0600339.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/60\/3\/339\/452750\/cs0600339.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:00:24Z","timestamp":1638478824000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/60\/3\/339\/90158\/Human-Parathyroid-Gland-Adenylate-Cyclase-Activity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0600339","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3,1]]}}}