{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:54:13Z","timestamp":1715540053386},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,5,1]]},"abstract":"<jats:p>1. We have examined the inter-relationships between erythrocyte sodium content and sodium transport in a group of healthy subjects and in groups of patients with disorders known to change the sodium content of erythrocytes.<\/jats:p>\n               <jats:p>2. In the healthy subjects the sodium content of erythrocytes was inversely related to both the permeability of the erythrocyte membrane to sodium (as measured by the unidirectional, ouabain-sensitive, sodium efflux) and the total activity of the sodium pumps (as measured by the rate constant of ouabain-sensitive sodium efflux). There was a correlation between the total activity of the sodium pumps and the membrane permeability to sodium.<\/jats:p>\n               <jats:p>3. Changes in the erythrocyte sodium content were due to a decrease in the activity of the sodium pumps (as in hypokalaemia and digoxin treatment), or a decrease in the permeability of the erythrocyte membrane to sodium (as in chronic renal failure) or a reduction of both the membrane permeability and the number of sodium pumps (as in hyperthyroidism or elderly patients).<\/jats:p>\n               <jats:p>4. One interpretation of the results in the healthy subjects is that there are two components of sodium influx; one associated with the sodium pumps in what we have called \u2018membrane-units\u2019 and the other determined by the ground permeability of the membrane.<\/jats:p>\n               <jats:p>5. On the basis of this model we suggest that in the geriatric and hyperthyroid patients there is a reduction in the number of \u2018membrane-units\u2019, that in hypokalaemia and during digoxin treatment there is inhibition of the sodium-pump component of the \u2018membrane-units\u2019 and that in chronic renal failure there is a decrease in the permeability of the membrane to sodium.<\/jats:p>","DOI":"10.1042\/cs0600555","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:37:56Z","timestamp":1438943876000},"page":"555-564","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Relations between Sodium Transport and Sodium Concentration in Human Erythrocytes in Health and Disease"],"prefix":"10.1042","volume":"60","author":[{"given":"M.","family":"Cumberbatch","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, The General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, The General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/60\/5\/555\/452699\/cs0600555.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/60\/5\/555\/452699\/cs0600555.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:14:09Z","timestamp":1638476049000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/60\/5\/555\/72663\/Relations-between-Sodium-Transport-and-Sodium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0600555","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,5,1]]}}}