{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:28:56Z","timestamp":1771644536028,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,5,1]]},"abstract":"<jats:p>1. Responsiveness of the \u03b2-adrenoceptor adenylate cyclase system was measured in lymphocytes from healthy young and old subjects by incubating the cells with isoprenaline in the presence of a phosphodiesterase inhibitor and by measuring production of adenosine 3\u2032:5\u2032-cyclic monophosphate (cyclic AMP) with a competitive binding assay.<\/jats:p>\n               <jats:p>2. The two groups did not differ significantly in the levels of cyclic AMP produced or in the concentration of isoprenaline required to give half-maximal stimulation of the cells (ED50).<\/jats:p>","DOI":"10.1042\/cs0600587","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:37:56Z","timestamp":1438943876000},"page":"587-589","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Effect of Aging on \u03b2-Adrenoceptor-Stimulated Cyclic AMP Formation in Human Lymphocytes"],"prefix":"10.1042","volume":"60","author":[{"given":"C. A.","family":"Kraft","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Leicester, Leicester General Hospital, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Castleden","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Leicester, Leicester General Hospital, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/60\/5\/587\/452709\/cs0600587.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/60\/5\/587\/452709\/cs0600587.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:13:24Z","timestamp":1638476004000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/60\/5\/587\/72646\/The-Effect-of-Aging-on-Adrenoceptor-Stimulated"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0600587","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,5,1]]}}}