{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:06:33Z","timestamp":1758823593721},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,8,1]]},"abstract":"<jats:p>1. Plasma noradrenaline, active and inactive plasma renin, cardiac index and total peripheral vascular resistance were studied in 41 subjects, initially aged 10\u201319 years, who were followed up for at least 2 years after a blood pressure reading of 140 and\/or 90 mmHg or more (initial hypertensives) and in 41 normotensive control subjects selected from the same population and matched for age, sex and body-mass index.<\/jats:p>\n               <jats:p>2. The initial hypertensive subjects had a lower mean cardiac index (3.63 \u00b1 sd 0.83 vs 4.00 \u00b1 0.89 litre min\u22121 m\u22122), a higher mean total peripheral resistance (26.8 \u00b1 5.7 vs 22.8 \u00b1 5.5 units) and a higher mean plasma noradrenaline concentration (336 \u00b1 146 vs 281 \u00b1 126 pg\/ml) than the control subjects.<\/jats:p>\n               <jats:p>3. Mean plasma noradrenaline concentration was higher in initial hypertensive subjects with a high active renin concentration than in those with a normal renin concentration (442 \u00b1 70 vs 324 \u00b1 100 pg\/ml).<\/jats:p>\n               <jats:p>4. A weight-adjusted standardized regression coefficient of 0.77 between active plasma renin concentration and left ventricular mass was found in normotensive control subjects.<\/jats:p>\n               <jats:p>5. These findings are at variance with the existence of a hyperkinetic phase in young hypertensive subjects and suggest that sympathetic overactivity may be related to early essential hypertension through increase of peripheral vascular resistance.<\/jats:p>","DOI":"10.1042\/cs0610169","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"169-174","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Haemodynamics, Plasma Noradrenaline and Plasma Renin in Hypertensive and Normotensive Teenagers"],"prefix":"10.1042","volume":"61","author":[{"given":"A.","family":"Hofman","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Department of Clinical Echocardiography, Thoraxcentre and Department of Internal Medicine I, Medical Faculty, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. T. R. C.","family":"Roelandt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Department of Clinical Echocardiography, Thoraxcentre and Department of Internal Medicine I, Medical Faculty, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Boomsma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Department of Clinical Echocardiography, Thoraxcentre and Department of Internal Medicine I, Medical Faculty, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A. D. H.","family":"Schalekamp","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Department of Clinical Echocardiography, Thoraxcentre and Department of Internal Medicine I, Medical Faculty, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Valkenburg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Department of Clinical Echocardiography, Thoraxcentre and Department of Internal Medicine I, Medical Faculty, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/2\/169\/452907\/cs0610169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/2\/169\/452907\/cs0610169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:10:19Z","timestamp":1638475819000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/2\/169\/72560\/Haemodynamics-Plasma-Noradrenaline-and-Plasma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0610169","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,8,1]]}}}