{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T15:11:18Z","timestamp":1648825878960},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,8,1]]},"abstract":"<jats:p>1. The mineralocorticoid activity of 18-hydroxycorticosterone (18-OH-B) has been compared with that of aldosterone by using human bioassay in vivo with measurement of rectal potential difference and urinary log 10 Na+\/K+ ratio.<\/jats:p>\n               <jats:p>2. A log-linear relationship was found between maximum change in rectal potential difference and increasing doses of aldosterone.<\/jats:p>\n               <jats:p>3. No mineralocorticoid activity could be demonstrated after an intravenous bolus and infusion of 18-OH-B.<\/jats:p>\n               <jats:p>4. The half-life of clearance of 18-OH-B was measured in three subjects and found to be 28, 48 and 24 min.<\/jats:p>","DOI":"10.1042\/cs0610201","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"201-206","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the Mineralocorticoid Activity of 18-Hydroxycorticosterone"],"prefix":"10.1042","volume":"61","author":[{"given":"G.","family":"Huston","sequence":"first","affiliation":[{"name":"Departments of Clinical Pharmacology and Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. I.","family":"Martin","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pharmacology and Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A. S.","family":"Al-Dujaili","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pharmacology and Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R. W.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pharmacology and Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/2\/201\/453056\/cs0610201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/2\/201\/453056\/cs0610201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:11:31Z","timestamp":1638475891000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/2\/201\/72594\/Evaluation-of-the-Mineralocorticoid-Activity-of-18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0610201","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,8,1]]}}}