{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:24:26Z","timestamp":1791026666384,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,9,1]]},"abstract":"<jats:p>1. Five males were studied on three occasions, after oral administration of CaCO3 (control), NH4Cl (acidosis) and NaHCO3 (alkalosis), in a dose of 0.3 g\/kg, taken over a 3 h period at rest. The subjects then exercised on a cycle ergometer for 20 min at 33% maximal oxygen uptake (Vo2 max.), followed by 20 min at 66% and at 95% Vo2 max. until exhaustion.<\/jats:p>\n               <jats:p>2. Endurance at 95% Vo2 max. was longest with alkalosis (5.44 \u00b1 1.05 min), shortest with acidosis (3.13 \u00b1 0.97 min) and intermediate in the control study (4.56 \u00b1 1.31 min); venous blood pH at exhaustion was 7.33 \u00b1 0.02 (mean \u00b11 sem), 7.13 \u00b1 0.02 and 7.26 \u00b1 0.02 respectively.<\/jats:p>\n               <jats:p>3. Concentrations of plasma lactate at exhaustion were 7.10 \u00b1 0.8 mmol\/l 4.0 \u00b1 0.5 and 7.9 \u00b1 0.9 mmol\/l in the control, acidosis and alkalosis studies respectively.<\/jats:p>\n               <jats:p>4. Muscle lactate increased most from rest to exhaustion with alkalosis to 17.1 \u00b1 2.5 \u03bcmol\/g and least with acidosis to 12.2 \u00b1 1.4 \u03bcmol\/g. Muscle glycogen depletion was comparable in control and alkalosis studies.<\/jats:p>\n               <jats:p>5. The lower plasma lactate concentration during exercise in acidosis compared with control and alkalosis appears to be due to an inhibition of muscle glycolysis combined with a reduction in lactate efflux from muscle.<\/jats:p>","DOI":"10.1042\/cs0610331","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"331-338","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":175,"title":["Effect of pH on Muscle Glycolysis during Exercise"],"prefix":"10.1042","volume":"61","author":[{"given":"J. R.","family":"Sutton","sequence":"first","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Toews","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/3\/331\/458824\/cs0610331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/3\/331\/458824\/cs0610331.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:55:20Z","timestamp":1638478520000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/3\/331\/75740\/Effect-of-pH-on-Muscle-Glycolysis-during-Exercise"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0610331","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9,1]]}}}