{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:53:25Z","timestamp":1715540005492},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,10,1]]},"abstract":"<jats:p>1. In male mice without kidneys and submaxillary, as well as sublingual, glands aggressive behaviour causes a vast release of renin [J. Bing &amp; K. Poulsen (1979) Acta Physiologica Scandinavica, 107, 251\u2013256].<\/jats:p>\n               <jats:p>2. This resulted in about an 800-fold increase in plasma renin concentration from the control level of 0.52 (range 0.15-0.8) Goldblatt unit (G.U.) \u00d7 10\u22123\/ml to 430 (range 300\u2013500) G.U. \u00d7 10\u22123\/ml after aggression.<\/jats:p>\n               <jats:p>3. The aggression-provoked renin fulfil all the criteria so far studied for being active renin, identical with normal mouse plasma renin and pure submaxillary mouse renin.<\/jats:p>\n               <jats:p>4. It generates angiotensin I with renin substrate and Km (1.2 \u03bcmol\/l) is the same. It is neutralized by pepstatin but not by inhibitors of metallo-, thiol and serine proteinases, indicating that it is an aspartate proteinase (acidic proteinase).<\/jats:p>\n               <jats:p>5. It is a 40 000-mol.wt. renin, which has full enzymatic activity with a specific enzymatic activity of 0.32 G.U.\/\u03bcg, identical with that of normal plasma renin.<\/jats:p>\n               <jats:p>6. Its enzymatic activity is neutralized by a specific antibody against pure submaxillary renin. It is measurable in the direct renin radioimmunoassay with a dilution curve which parallels that of the standards. It demonstrates complete antigenic identity with pure submaxillary renin in crossed immunoelectrophoresis.<\/jats:p>\n               <jats:p>7. Its origin is unknown.<\/jats:p>","DOI":"10.1042\/cs0610373","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"373-378","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of Aggression-Provoked Renin from An Unknown Source in Male Mice"],"prefix":"10.1042","volume":"61","author":[{"given":"K.","family":"Poulsen","sequence":"first","affiliation":[{"name":"Institute for Biochemistry, The Royal Dental College, Jagtvej, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry, The Royal Dental College, Jagtvej, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/4\/373\/453093\/cs0610373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/4\/373\/453093\/cs0610373.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:19:20Z","timestamp":1638476360000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/4\/373\/72867\/Characterization-of-Aggression-Provoked-Renin-from"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0610373","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,10,1]]}}}