{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:53:08Z","timestamp":1760100788712},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,12,1]]},"abstract":"<jats:p>1. Stressful sympathetic stimulation (cold pressor test) was applied to 18 patients with essential hypertension and 15 normotensive subjects. Intra-arterial blood pressure, heart rate, plasma adrenaline and noradrenaline concentrations as well as forearm blood flow were measured before and during the cold pressor test; tests were repeated after regional postsynaptic \u03b11-adrenoceptor blockade with prazosin.<\/jats:p>\n               <jats:p>2. Under basal conditions mean blood pressure (P &amp;lt; 0.001), heart rate (P &amp;lt; 0.01), forearm blood flow (P &amp;lt; 0.001) as well as adrenaline concentration (P &amp;lt; 0.01), but not noradrenaline, was higher in patients with essential hypertension.<\/jats:p>\n               <jats:p>3. During the cold pressor test, mean blood pressure, heart rate, plasma adrenaline and noradrenaline concentrations increased and forearm flow decreased (all P &amp;lt; 0.001).<\/jats:p>\n               <jats:p>4. Stress-stimulated plasma adrenaline was higher in essential hypertensive patients than in normotensive subjects (P &amp;lt; 0.01). In the former the stress-induced increase in plasma adrenaline correlated with the increase in mean blood pressure (r = 0.514; P &amp;lt; 0.05).<\/jats:p>\n               <jats:p>5. Prazosin increased forearm blood flow more in essential hypertension (P &amp;lt; 0.001). This increase correlated with the resting plasma adrenaline in the hypertensive (r = 0.710; P &amp;lt; 0.001), but not in normotensive, subjects.<\/jats:p>\n               <jats:p>6. When the cold pressor test was repeated during postsynaptic \u03b11-adrenoceptor blockade forearm blood flow did not decrease; instead it increased further in both groups (P &amp;lt; 0.05).<\/jats:p>\n               <jats:p>7. Thus in essential hypertension elevated plasma adrenaline concentration reflects sympathetic overactivity as also expressed by enhanced \u03b1-adrenoceptor-mediated vasoconstriction.<\/jats:p>","DOI":"10.1042\/cs061161s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"161s-164s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Elevated Plasma Adrenaline Reflects Sympathetic Overactivity and Enhanced \u03b1-Adrenoceptor-Mediated Vasoconstriction in Essential Hypertension"],"prefix":"10.1042","volume":"61","author":[{"given":"P.","family":"Bolli","sequence":"first","affiliation":[{"name":"Department of Medicine and Department of Research, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. W.","family":"Amann","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Research, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hulth\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Research, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kiowski","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Research, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. R.","family":"B\u00fchler","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Research, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/161s\/876673\/cs061161s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/161s\/876673\/cs061161s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:22:22Z","timestamp":1638480142000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/s7\/161s\/102385\/Elevated-Plasma-Adrenaline-Reflects-Sympathetic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12,1]]},"references-count":0,"journal-issue":{"issue":"s7","published-print":{"date-parts":[[1981,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs061161s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1981,12,1]]}}}