{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:53:23Z","timestamp":1715540003850},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,12,1]]},"abstract":"<jats:p>1. Plasma noradrenaline concentrations and platelet \u03b1-receptor properties were measured in 14 normal subjects, five phaeochromocytoma patients and nine patients with multiple system atrophy and sympathetic nervous system degeneration (MSA).<\/jats:p>\n               <jats:p>2. Plasma noradrenaline concentrations in phaeochromocytoma were 10- to 20-times greater than those of normal subjects and one-fifth to one-half of normal in MSA patients.<\/jats:p>\n               <jats:p>3. Platelet \u03b1-receptor numbers were increased in MSA and decreased in phaeochromocytoma compared with normal subjects. There was no change in platelet \u03b1-receptor affinity in either group.<\/jats:p>\n               <jats:p>4. The inverse relationship between \u03b1-receptor numbers and plasma noradrenaline concentrations may reflect regulation of \u03b1-receptor number by endogenous adrenergic agonist concentrations in man.<\/jats:p>","DOI":"10.1042\/cs061207s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"207s-210s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Endogenous Agonist Regulation of \u03b1-Adrenoceptors in Man"],"prefix":"10.1042","volume":"61","author":[{"given":"I. B.","family":"Davies","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sudera","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Sever","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/207s\/876687\/cs061207s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/207s\/876687\/cs061207s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:22:23Z","timestamp":1638480143000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/s7\/207s\/102388\/Endogenous-Agonist-Regulation-of-Adrenoceptors-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12,1]]},"references-count":0,"journal-issue":{"issue":"s7","published-print":{"date-parts":[[1981,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs061207s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1981,12,1]]}}}